| |  Online-Ressource |
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| Verfasst von: | Kespohl, Meike [VerfasserIn]  |
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| | Bredow, Clara [VerfasserIn] |
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| | Klingel, Karin [VerfasserIn] |
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| | Voß, Martin [VerfasserIn] |
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| | Paeschke, Anna [VerfasserIn] |
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| | Zickler, Martin [VerfasserIn] |
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| | Poller, Wolfgang [VerfasserIn] |
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| | Kaya, Ziya [VerfasserIn] |
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| | Eckstein, Johannes [VerfasserIn] |
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| | Fechner, Henry [VerfasserIn] |
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| | Spranger, Joachim [VerfasserIn] |
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| | Fähling, Michael [VerfasserIn] |
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| | Wirth, Eva Katrin [VerfasserIn] |
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| | Radoshevich, Lilliana [VerfasserIn] |
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| | Thery, Fabien [VerfasserIn] |
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| | Impens, Francis [VerfasserIn] |
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| | Berndt, Nikolaus [VerfasserIn] |
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| | Knobeloch, Klaus-Peter [VerfasserIn] |
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| | Beling, Antje [VerfasserIn] |
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| Titel: | Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming |
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| Verf.angabe: | Meike Kespohl, Clara Bredow, Karin Klingel, Martin Voß, Anna Paeschke, Martin Zickler, Wolfgang Poller, Ziya Kaya, Johannes Eckstein, Henry Fechner, Joachim Spranger, Michael Fähling, Eva Katrin Wirth, Lilliana Radoshevich, Fabien Thery, Francis Impens, Nikolaus Berndt, Klaus-Peter Knobeloch, Antje Beling |
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| E-Jahr: | 2020 |
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| Jahr: | 11 March 2020 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 07.05.2020 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 6(2020,11) Artikel-Nummer eaay1109, 19 Seiten |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | Protein modification with ISG15 (ISGylation) represents a major type I IFN-induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation, however, are still ill defined and controversial. We used a multiphasic coxsackievirus B3 (CV) infection model with a first wave resulting in hepatic injury of the liver, followed by a second wave culminating in cardiac damage. This study shows that ISGylation sets nonhematopoietic cells into a resistant state, being indispensable for CV control, which is accomplished by synergistic activity of ISG15 on antiviral IFIT1/3 proteins. Concurrent with altered energy demands, ISG15 also adapts liver metabolism during infection. Shotgun proteomics, in combination with metabolic network modeling, revealed that ISG15 increases the oxidative capacity and promotes gluconeogenesis in liver cells. Cells lacking the activity of the ISG15-specific protease USP18 exhibit increased resistance to clinically relevant CV strains, therefore suggesting that stabilizing ISGylation by inhibiting USP18 could be exploited for CV-associated human pathologies. - Protein modification with ISG15 acts cooperatively with IFIT proteins and preserves glucose homeostasis. - Protein modification with ISG15 acts cooperatively with IFIT proteins and preserves glucose homeostasis. |
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| DOI: | doi:10.1126/sciadv.aay1109 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/sciadv.aay1109 |
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| | Volltext: https://advances.sciencemag.org/content/6/11/eaay1109 |
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| | DOI: https://doi.org/10.1126/sciadv.aay1109 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1697697038 |
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| Verknüpfungen: | → Zeitschrift |
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Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming / Kespohl, Meike [VerfasserIn]; 11 March 2020 (Online-Ressource)
