Status: Bibliographieeintrag
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| Verfasst von: | Salar, Seda [VerfasserIn]  |
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| | Lapilover, Ezequiel [VerfasserIn] |
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| | Müller, Julia [VerfasserIn] |
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| | Hollnagel, Jan-Oliver [VerfasserIn] |
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| | Lippmann, Kristina [VerfasserIn] |
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| | Friedman, Alon [VerfasserIn] |
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| | Heinemann, Uwe [VerfasserIn] |
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| Titel: | Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin |
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| Verf.angabe: | Seda Salar, Ezequiel Lapilover, Julia Müller, Jan-Oliver Hollnagel, Kristina Lippmann, Alon Friedman, Uwe Heinemann |
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| E-Jahr: | 2016 |
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| Jahr: | 10 March 2016 |
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| Umfang: | 11 S. |
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| Teil: | volume:91 |
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| | year:2016 |
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| | pages:155-165 |
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| | extent:11 |
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| Fussnoten: | Gesehen am 07.05.2020 |
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| Titel Quelle: | Enthalten in: Neurobiology of disease |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1994 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 91(2016), Seite 155-165 |
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| ISSN Quelle: | 1095-953X |
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| Abstract: | Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocortical photothrombotic stroke, we previously demonstrated abnormal activity-dependent accumulation of extracellular potassium with facilitated generation of seizure like events and spreading depolarizations. Similar changes could be observed after intracerebroventricular (icv) application of albumin. We hypothesized that alterations in extracellular potassium and glutamate homeostasis might lead to alterations in synaptic interactions. We therefore assessed the effects of icv albumin on homo- and heterosynaptic plasticity in hippocampal CA1, 24h after a single injection or 7days after continuous infusion of icv albumin. We demonstrate alterations in both homo- and heterosynaptic plasticity compared to control conditions in ex vivo slice studies. |
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| DOI: | doi:10.1016/j.nbd.2016.03.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.nbd.2016.03.008 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0969996116300523 |
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| | DOI: https://doi.org/10.1016/j.nbd.2016.03.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Albumin |
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| | Blood-brain barrier |
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| | Epilepsy |
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| | Hippocampus |
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| | Hyperexcitability |
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| | Synaptic plasticity |
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| K10plus-PPN: | 1697705154 |
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| Verknüpfungen: | → Zeitschrift |
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Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin / Salar, Seda [VerfasserIn]; 10 March 2016 (Online-Ressource)
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