Structural analysis of bovine norovirus protruding domain

• Verfasst von: Singh, Bishal [VerfasserIn]
• Verfasst von: Koromyslova, Anna D. [VerfasserIn]
• Verfasst von: Hansman, Grant S. [VerfasserIn]
• Titel: Structural analysis of bovine norovirus protruding domain
• Verf.angabe: Bishal Kumar Singh, Anna Koromyslova, Grant S. Hansman
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 6 S.
• Fussnoten: Available online 18 November 2015 ; Gesehen am 08.05.2020
• Titel Quelle: Enthalten in: Virology
• Ort Quelle: San Diego, Calif. [u.a.] : Elsevier, 1955
• Jahr Quelle: 2016
• Band/Heft Quelle: 487(2016), Seite 296-301
• ISSN Quelle: 1096-0341
• DOI: doi:10.1016/j.virol.2015.10.022
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antibodies
• Sach-SW: Bovine norovirus
• Sach-SW: Cross-reactivity
• K10plus-PPN: 1697719570

Abstract

We determined a structure of a bovine (genogroup III, GIII) norovirus capsid protruding (P) domain using X-ray crystallography. The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain. We also identified a monoclonal antibody that was capable of binding the five different (GI-GV) P domains. Our data suggests that genetically diverse noroviruses still contain common epitopes.