Online-Ressource | |
Verfasst von: | Singh, Bishal [VerfasserIn] |
Leuthold, Mila [VerfasserIn] | |
Hansman, Grant S. [VerfasserIn] | |
Titel: | Structural constraints on human norovirus binding to histo-blood group antigens |
Verf.angabe: | Bishal K. Singh, Mila M. Leuthold, Grant S. Hansman |
E-Jahr: | 2016 |
Jahr: | 30 March 2016 |
Fussnoten: | Gesehen am 08.05.2020 |
Titel Quelle: | Enthalten in: mSphere |
Ort Quelle: | Washington DC : American Society for Microbiology, 2016 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 1(2016,2) Artikel-Nummer e00049-16, 7 Seiten |
ISSN Quelle: | 2379-5042 |
Abstract: | Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions with different HBGA types. Most human noroviruses bind HBGAs, while some strains were found to have minimal or no HBGA interactions. Here, we explain some possible structural constraints for several noroviruses that were found to bind poorly to HBGAs by using X-ray crystallography. We showed that one aspartic acid was flexible or positioned away from the fucose moiety of the HBGAs and this likely hindered binding, although other fucose-interacting residues were perfectly oriented. Interestingly, a neighboring loop also appeared to influence the loop hosting the aspartic acid. These new findings might explain why some human noroviruses bound HBGAs poorly, although further studies are required. |
DOI: | doi:10.1128/mSphere.00049-16 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext ; Verlag: https://doi.org/10.1128/mSphere.00049-16 |
Volltext: https://msphere.asm.org/content/1/2/e00049-16 | |
DOI: https://doi.org/10.1128/mSphere.00049-16 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1697722741 |
Verknüpfungen: | → Zeitschrift |