| |  Online-Ressource |
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| Verfasst von: | Rauber, Conrad [VerfasserIn]  |
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| | Awad, Miriam [VerfasserIn] |
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| | Koschny, Ronald [VerfasserIn] |
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| | Sauer, Peter [VerfasserIn] |
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| | Mehrabi, Arianeb [VerfasserIn] |
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| | Gath, Philip [VerfasserIn] |
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| | Weiss, Karl Heinz [VerfasserIn] |
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| | Gotthardt, Daniel [VerfasserIn] |
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| | Rupp, Christian [VerfasserIn] |
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| Titel: | Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are associated with biliary damage and graft survival in a case-control study |
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| Verf.angabe: | Conrad Rauber, Miriam Awad, Ronald Koschny, Peter Sauer, Arianeb Mehrabi, Philip Gath, Karl-Heinz Weiss, Daniel Nils Gotthardt, Christian Rupp |
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| Jahr: | 2020 |
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| Jahr des Originals: | 2019 |
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| Umfang: | 11 S. |
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| Fussnoten: | Online 11 June 2019 ; Gesehen am 11.05.2020 |
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| Titel Quelle: | Enthalten in: Clinics and research in hepatology and gastroenterology |
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| Ort Quelle: | Amsterdam : Elsevier Masson, 2011 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 44(2020), 1, Seite 38-48 |
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| ISSN Quelle: | 2210-741X |
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| Abstract: | Background - After liver transplantation (LT), biliary complications are associated with reduced graft survival. We tested inflammation markers for their association with biliary damage and graft loss in bile. - Material and methods - The study design was a retrospective case-control study. Calprotectin, lactoferrin and pyruvate kinase were measured in endoscopically retrieved bile with ELISA. - Results - Calprotectin and lactoferrin were significantly higher in bile of ischemic-type biliary lesions and donor duct non-anastomotic strictures than in control, bile leakage, Cytomegalovirus infection, anastomotic stricture or acute cellular rejection patients (p<0.001) independent of serum liver values at endoscopy. Calprotectin (p=0.02) was independently associated with retransplantation free survival in multivariate analysis, as was γGT (p=0.03) but not ERC radiographic classification of the bile duct or cold ischemia time. - Conclusion - Calprotectin and lactoferrin are bile markers for biliary damage and are associated with re-transplantation free survival. They can differentiate progressive biliary damage from non-biliary liver value alterations after LT. |
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| DOI: | doi:10.1016/j.clinre.2019.05.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.clinre.2019.05.005 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2210740119301020 |
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| | DOI: https://doi.org/10.1016/j.clinre.2019.05.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biliary stricture |
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| | Calprotectin |
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| | Lactoferrin |
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| | Liver transplantation |
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| | Pyruvate kinase |
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| | Rejection |
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| K10plus-PPN: | 169782689X |
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| Verknüpfungen: | → Zeitschrift |
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Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are associated with biliary damage and graft survival in a case-control study / Rauber, Conrad [VerfasserIn]; 2020 (Online-Ressource)
