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Verfasst von:Jarasch, Nadine [VerfasserIn]   i
 Goetzke, Carl Christoph [VerfasserIn]   i
 Kespohl, Meike [VerfasserIn]   i
 Voss, Karolin [VerfasserIn]   i
 Heuser, Arnd [VerfasserIn]   i
 Pinkert, Sandra [VerfasserIn]   i
 Kaya, Ziya [VerfasserIn]   i
 Klingel, Karin [VerfasserIn]   i
 Beling, Antje [VerfasserIn]   i
Titel:The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis
Verf.angabe:Nadine Althof, Carl Christoph Goetzke, Meike Kespohl, Karolin Voss, Arnd Heuser, Sandra Pinkert, Ziya Kaya, Karin Klingel & Antje Beling
E-Jahr:2018
Jahr:2 January 2018
Umfang:19 S.
Fussnoten:Gesehen am 11.05.2020
Titel Quelle:Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine
Ort Quelle:[London] : Nature Publishing Group UK, 2009
Jahr Quelle:2018
Band/Heft Quelle:10(2018), 2, Seite 200-218
ISSN Quelle:1757-4684
Abstract:Abstract Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing immune factors. Utilizing a murine model with high susceptibility to coxsackievirus B3-induced myocarditis, this study describes ONX 0914?an immunoproteasome-specific inhibitor?as highly protective during severe heart disease. Represented by reduced heart infiltration of monocytes/macrophages and diminished organ damage, ONX 0914 treatment reversed fulminant pathology. Virus-induced immune response features like overwhelming pro-inflammatory cytokine and chemokine production as well as a progressive loss of lymphocytes all being reminiscent of a sepsis-like disease course were prevented by ONX 0914. Although the viral burden was only minimally affected in highly susceptible mice, resulting maintenance of immune homeostasis improved the cardiac output, and saved animals from severe illness as well as high mortality. Altogether, this could make ONX 0914 a potent drug for the treatment of severe virus-mediated inflammation of the heart and might rank immunoproteasome inhibitors among drugs for preventing pathogen-induced immunopathology.
DOI:doi:10.15252/emmm.201708089
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.15252/emmm.201708089
 Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201708089
 DOI: https://doi.org/10.15252/emmm.201708089
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:immunology and inflammation
 infectious diseases
 myocarditis
 proteasome
 virus
K10plus-PPN:169785138X
Verknüpfungen:→ Zeitschrift

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