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| Verfasst von: | Jarasch, Nadine [VerfasserIn]  |
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| | Goetzke, Carl Christoph [VerfasserIn] |
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| | Kespohl, Meike [VerfasserIn] |
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| | Voss, Karolin [VerfasserIn] |
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| | Heuser, Arnd [VerfasserIn] |
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| | Pinkert, Sandra [VerfasserIn] |
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| | Kaya, Ziya [VerfasserIn] |
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| | Klingel, Karin [VerfasserIn] |
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| | Beling, Antje [VerfasserIn] |
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| Titel: | The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis |
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| Verf.angabe: | Nadine Althof, Carl Christoph Goetzke, Meike Kespohl, Karolin Voss, Arnd Heuser, Sandra Pinkert, Ziya Kaya, Karin Klingel & Antje Beling |
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| E-Jahr: | 2018 |
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| Jahr: | 2 January 2018 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 11.05.2020 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2009 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 10(2018), 2, Seite 200-218 |
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| ISSN Quelle: | 1757-4684 |
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| Abstract: | Abstract Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing immune factors. Utilizing a murine model with high susceptibility to coxsackievirus B3-induced myocarditis, this study describes ONX 0914?an immunoproteasome-specific inhibitor?as highly protective during severe heart disease. Represented by reduced heart infiltration of monocytes/macrophages and diminished organ damage, ONX 0914 treatment reversed fulminant pathology. Virus-induced immune response features like overwhelming pro-inflammatory cytokine and chemokine production as well as a progressive loss of lymphocytes all being reminiscent of a sepsis-like disease course were prevented by ONX 0914. Although the viral burden was only minimally affected in highly susceptible mice, resulting maintenance of immune homeostasis improved the cardiac output, and saved animals from severe illness as well as high mortality. Altogether, this could make ONX 0914 a potent drug for the treatment of severe virus-mediated inflammation of the heart and might rank immunoproteasome inhibitors among drugs for preventing pathogen-induced immunopathology. |
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| DOI: | doi:10.15252/emmm.201708089 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/emmm.201708089 |
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| | Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201708089 |
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| | DOI: https://doi.org/10.15252/emmm.201708089 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | immunology and inflammation |
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| | infectious diseases |
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| | myocarditis |
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| | proteasome |
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| | virus |
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| K10plus-PPN: | 169785138X |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis / Jarasch, Nadine [VerfasserIn]; 2 January 2018 (Online-Ressource)
