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Verfasst von:Biller, Armin [VerfasserIn]   i
 Pflugmann, Isabella [VerfasserIn]   i
 Badde, Stephanie [VerfasserIn]   i
 Diem, Ricarda [VerfasserIn]   i
 Wildemann, Brigitte [VerfasserIn]   i
 Nagel, Armin Michael [VerfasserIn]   i
 Jordan, J. [VerfasserIn]   i
 Benkhedah, Nadia [VerfasserIn]   i
 Kleesiek, Jens Philipp [VerfasserIn]   i
Titel:Sodium MRI in multiple sclerosis is compatible with intracellular sodium accumulation and inflammation-induced hyper-cellularity of acute Brain Lesions
Verf.angabe:Armin Biller, Isabella Pflugmann, Stephanie Badde, Ricarda Diem, Brigitte Wildemann, Armin M. Nagel, J. Jordan, Nadia Benkhedah, & Jens Kleesiek
E-Jahr:2016
Jahr:10 August 2016
Umfang:10 S.
Fussnoten:Gesehen am 12.05.2020
Titel Quelle:Enthalten in: Scientific reports
Ort Quelle:[London] : Macmillan Publishers Limited, part of Springer Nature, 2011
Jahr Quelle:2016
Band/Heft Quelle:6(2016) Artikel-Nummer 31269, 10 Seiten
ISSN Quelle:2045-2322
Abstract:The cascade of inflammatory pathogenetic mechanisms in multiple sclerosis (MS) has no specific conventional MRI correlates. Clinicians therefore stipulate improved imaging specificity to define the pathological substrates of MS in vivo including mapping of intracellular sodium accumulation. Based upon preclinical findings and results of previous sodium MRI studies in MS patients we hypothesized that the fluid-attenuated sodium signal differs between acute and chronic lesions. We acquired brain sodium and proton MRI data of N = 29 MS patients; lesion type was defined by the presence or absence of contrast enhancement. N = 302 MS brain lesions were detected, and generalized linear mixed models were applied to predict lesion type based on sodium signals; thereby controlling for varying numbers of lesions among patients and confounding variables such as age and medication. Hierarchical model comparisons revealed that both sodium signals average tissue (χ2(1) = 27.89, p < 0.001) and fluid-attenuated (χ2(1) = 5.76, p = 0.016) improved lesion type classification. Sodium MRI signals were significantly elevated in acute compared to chronic lesions compatible with intracellular sodium accumulation in acute MS lesions. If confirmed in further studies, sodium MRI could serve as biomarker for diagnostic assessment of MS, and as readout parameter in clinical trials promoting attenuation of chronic inflammation.
DOI:doi:10.1038/srep31269
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1038/srep31269
 Volltext: https://www.nature.com/articles/srep31269
 DOI: https://doi.org/10.1038/srep31269
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1698022530
Verknüpfungen:→ Zeitschrift

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