Risk factors for incident diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years

• Verfasst von: Andersen, Signe Toft [VerfasserIn]
• Verfasst von: Witte, Daniel R. [VerfasserIn]
• Verfasst von: Dalsgaard, Else-Marie [VerfasserIn]
• Verfasst von: Andersen, Henning [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Fleming, Thomas [VerfasserIn]
• Verfasst von: Jensen, Troels M. [VerfasserIn]
• Verfasst von: Finnerup, Nanna B. [VerfasserIn]
• Verfasst von: Jensen, Troels S. [VerfasserIn]
• Verfasst von: Lauritzen, Torsten [VerfasserIn]
• Verfasst von: Feldman, Eva L. [VerfasserIn]
• Verfasst von: Callaghan, Brian C. [VerfasserIn]
• Verfasst von: Charles, Morten [VerfasserIn]
• Titel: Risk factors for incident diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years
• Titelzusatz: ADDITION-Denmark
• Verf.angabe: Signe T. Andersen, Daniel R. Witte, Else-Marie Dalsgaard, Henning Andersen, Peter Nawroth, Thomas Fleming, Troels M. Jensen, Nanna B. Finnerup, Troels S. Jensen, Torsten Lauritzen, Eva L. Feldman, Brian C. Callaghan, and Morten Charles
• E-Jahr: 2018
• Jahr: 6 February 2018
• Umfang: 8 S.
• Fussnoten: Gesehen am 14.05.2020
• Titel Quelle: Enthalten in: Diabetes care
• Ort Quelle: Alexandria, Va. : Assoc., 1978
• Jahr Quelle: 2018
• Band/Heft Quelle: 41(2018), 5, Seite 1068-1075
• ISSN Quelle: 1935-5548
• DOI: doi:10.2337/dc17-2062
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1698273207

Abstract

OBJECTIVE To study incident diabetic polyneuropathy (DPN) prospectively during the first 13 years after a screening-based diagnosis of type 2 diabetes and determine the associated risk factors for the development of DPN. - RESEARCH DESIGN AND METHODS We assessed DPN longitudinally in the Danish arm of the Anglo-Danish-Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION) using the Michigan Neuropathy Screening Instrument questionnaire (MNSIQ), defining DPN with scores ≥4. Risk factors present at the diabetes diagnosis associated with the risk of incident DPN were estimated using Cox proportional hazard models adjusted for trial randomization group, sex, and age. - RESULTS Of the total cohort of 1,533 people, 1,445 completed the MNSIQ at baseline and 189 (13.1%) had DPN at baseline. The remaining 1,256 without DPN entered this study (median age 60.8 years [interquartile range 55.6; 65.6], 59% of whom were men). The cumulative incidence of DPN was 10% during 13 years of diabetes. Age (hazard ratio [HR] 1.03 [95% CI 1.00; 1.07]) (unit = 1 year), weight (HR 1.09 [95% CI 1.03; 1.16]) (unit = 5 kg), waist circumference (HR 1.14 [95% CI 1.05; 1.24]) (unit = 5 cm), BMI (HR 1.14 [95% CI 1.06; 1.23]) (unit = 2 kg/m2), log2 methylglyoxal (HR 1.45 [95% CI 1.12; 1.89]) (unit = doubling), HDL cholesterol (HR 0.82 [95% CI 0.69; 0.99]) (unit = 0.25 mmol/L), and LDL cholesterol (HR 0.92 [95% CI 0.86; 0.98]) (unit = 0.25 mmol/L) at baseline were significantly associated with the risk of incident DPN. - CONCLUSIONS This study provides further epidemiological evidence for obesity as a risk factor for DPN. Moreover, low HDL cholesterol levels and higher levels of methylglyoxal, a marker of dicarbonyl stress, are identified as risk factors for the development of DPN.