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Verfasst von:Sporns, Peter B. [VerfasserIn]   i
 Sträter, Dirk Ronald [VerfasserIn]   i
 Minnerup, Jens [VerfasserIn]   i
 Wiendl, Heinz [VerfasserIn]   i
 Hanning, Uta [VerfasserIn]   i
 Chapot, René [VerfasserIn]   i
 Henkes, Hans [VerfasserIn]   i
 Henkes, Elina [VerfasserIn]   i
 Grams, Astrid [VerfasserIn]   i
 Dorn, Franziska [VerfasserIn]   i
 Nikoubashman, Omid [VerfasserIn]   i
 Wiesmann, Martin [VerfasserIn]   i
 Bier, Georg Andreas [VerfasserIn]   i
 Weber, Anushe Helena [VerfasserIn]   i
 Broocks, Gabriel [VerfasserIn]   i
 Fiehler, Jens [VerfasserIn]   i
 Brehm, Alex [VerfasserIn]   i
 Psychogios, Marios [VerfasserIn]   i
 Kaiser, Daniel [VerfasserIn]   i
 Yilmaz, Umut [VerfasserIn]   i
 Morotti, Andrea [VerfasserIn]   i
 Marik, Wolfgang [VerfasserIn]   i
 Nolz, Richard [VerfasserIn]   i
 Jensen-Kondering, Ulf [VerfasserIn]   i
 Schmitz, Bernd [VerfasserIn]   i
 Schob, Stefan [VerfasserIn]   i
 Beuing, Oliver [VerfasserIn]   i
 Götz, Friedrich [VerfasserIn]   i
 Trenkler, Johannes [VerfasserIn]   i
 Turowski, Bernd [VerfasserIn]   i
 Möhlenbruch, Markus Alfred [VerfasserIn]   i
 Wendl, Christina M. [VerfasserIn]   i
 Schramm, Peter [VerfasserIn]   i
 Musolino, Patricia [VerfasserIn]   i
 Lee, Sarah [VerfasserIn]   i
 Schlamann, Marc [VerfasserIn]   i
 Radbruch, Alexander [VerfasserIn]   i
 Rübsamen, Nicole [VerfasserIn]   i
 Karch, André [VerfasserIn]   i
 Heindel, Walter [VerfasserIn]   i
 Wildgruber, Moritz [VerfasserIn]   i
 Kemmling, Andre [VerfasserIn]   i
Titel:Does device selection impact recanalization rate and neurological outcome?
Titelzusatz:an analysis of the Save ChildS study
Verf.angabe:Sporns Peter B., Straeter Ronald, Minnerup Jens, Wiendl Heinz, Hanning Uta, Chapot René, Henkes Hans, Henkes Elina, Grams Astrid, Dorn Franziska, Nikoubashman Omid, Wiesmann Martin, Bier Georg, Weber Anushe, Broocks Gabriel, Fiehler Jens, Brehm Alex, Psychogios Marios, Kaiser Daniel, Yilmaz Umut, Morotti Andrea, Marik Wolfgang, Nolz Richard, Jensen-Kondering Ulf, Schmitz Bernd, Schob Stefan, Beuing Oliver, Goetz Friedrich, Trenkler Johannes, Turowski Bernd, Möhlenbruch Markus, Wendl Christina, Schramm Peter, Musolino Patricia, Lee Sarah, Schlamann Marc, Radbruch Alexander, Rübsamen Nicole, Karch André, Heindel Walter, Wildgruber Moritz, Kemmling André, and on behalf of Save ChildS Investigators
E-Jahr:2020
Jahr:2 March 2020
Umfang:8 S.
Fussnoten:Gesehen am 18.05.2020
Titel Quelle:Enthalten in: Stroke
Ort Quelle:New York, NY : Association, 1970
Jahr Quelle:2020
Band/Heft Quelle:51(2020), 4, Seite 1182-1189
ISSN Quelle:1524-4628
Abstract:Background and Purpose - The recent Save ChildS study provides multicenter evidence for the use of mechanical thrombectomy in children with large vessel occlusion arterial ischemic stroke. However, device selection for thrombectomy may influence rates of recanalization, complications, and neurological outcomes, especially in pediatric patients of different ages. We, therefore, performed additional analyses of the Save ChildS data to investigate a possible association of different thrombectomy techniques and devices with angiographic and clinical outcome parameters.Methods - The Save ChildS cohort study (January 2000-December 2018) analyzed data from 27 European and United States stroke centers and included all pediatric patients (<18 years), diagnosed with arterial ischemic stroke who underwent endovascular recanalization. Patients were grouped into first-line contact aspiration (A Direct Aspiration First Pass Technique [ADAPT]) and non-ADAPT groups as well as different stent retriever size groups. Associations with baseline characteristics, recanalization rates (modified Treatment in Cerebral Infarction), complication rates, and neurological outcome parameters (Pediatric National Institutes of Health Stroke Scale after 24 hours and 7 days; modified Rankin Scale and Pediatric Stroke Outcome Measure at discharge, after 6 and 24 months) were investigated.Results - Seventy-three patients with a median age of 11.3 years were included. Currently available stent retrievers were used in 59 patients (80.8%), of which 4×20 mm (width×length) was the most frequently chosen size (36 patients =61%). A first-line ADAPT approach was used in 7 patients (9.6%), and 7 patients (9.6%) were treated with first-generation thrombectomy devices. In this study, a first-line ADAPT approach was neither associated with the rate of successful recanalization (ADAPT 85.7% versus 87.5% No ADAPT) nor with the complication rate or the neurological outcome. Moreover, there were no associations of stent retriever sizes with rates of recanalization, complication rates, or outcome parameters.Conclusions - Our study suggests that neurological outcomes are generally good regardless of any specific device selection and suggests that it is important to offer thrombectomy in eligible children regardless of technique or device selection.Registration—URL: https://www.drks.de/; Unique identifier: DRKS00016528.
DOI:doi:10.1161/STROKEAHA.119.028221
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1161/STROKEAHA.119.028221
 Volltext: https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028221
 DOI: https://doi.org/10.1161/STROKEAHA.119.028221
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1698469799
Verknüpfungen:→ Zeitschrift

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