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Status: Bibliographieeintrag

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Verfasst von:Loureiro, Joana A. [VerfasserIn]   i
 Gomes, Bárbara [VerfasserIn]   i
 Fricker, Gert [VerfasserIn]   i
 Coelho, Manuel A. N. [VerfasserIn]   i
 Rocha, Sandra [VerfasserIn]   i
 Pereira, Maria Carmo [VerfasserIn]   i
Titel:Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment
Verf.angabe:Joana A. Loureiro, Bárbara Gomes, Gert Fricker, Manuel A.N. Coelho, Sandra Rocha, Maria Carmo Pereira
E-Jahr:2016
Jahr:20 April 2016
Umfang:6 S.
Fussnoten:Gesehen am 18.05.2020
Titel Quelle:Enthalten in: Colloids and surfaces / B
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1993
Jahr Quelle:2016
Band/Heft Quelle:145(2016), Seite 8-13
ISSN Quelle:1873-4367
Abstract:During the last few decades, relevant efforts have been reported to design nanocarriers for drug transport through the blood brain barrier (BBB). New drugs, such as peptide iAβ5, capable to inhibit the aggregates associated with Alzheimeŕs disease (AD) are being tested but the most frequent drawback is to reach the brain in the desired concentrations due to the low BBB permeability-surface area. Our approach, as a proof of concept to improve drug transport through the BBB, is based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles with surface functionalized with anti-transferrin receptor monoclonal antibody (OX26) and anti-Aβ (DE2B4) to deliver encapsulated iAβ5 into the brain. Porcine brain capillary endothelial cells (PBCECs) were used as a BBB model to evaluate the system efficacy and toxicity. The uptake of immune nanoparticles with a controlled delivery of the peptide iAβ5 was substantially increased compared to the nanoparticles (NPs) without monoclonal antibody functionalization.
DOI:doi:10.1016/j.colsurfb.2016.04.041
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.colsurfb.2016.04.041
 DOI: https://doi.org/10.1016/j.colsurfb.2016.04.041
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Alzheimer Disease
 Alzheimer’s disease
 Amyloid
 Animals
 Antibodies
 Blood brain-barrier
 Blood-Brain Barrier
 Brain
 Drug delivery systems
 Immuno nanoparticles
 Lactic Acid
 Nanoparticles
 Polyglycolic Acid
 Polylactic Acid-Polyglycolic Acid Copolymer
 Receptors, Transferrin
 Swine
 Therapeutic peptides
K10plus-PPN:1698490917
Verknüpfungen:→ Zeitschrift

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