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| Verfasst von: | Korkmaz-İçöz, Sevil [VerfasserIn]  |
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| | Atmanli, Ayhan [VerfasserIn] |
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| | Radovits, Tamás [VerfasserIn] |
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| | Li, Shiliang [VerfasserIn] |
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| | Hegedűs, Péter [VerfasserIn] |
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| | Ruppert, Mihály [VerfasserIn] |
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| | Brlecic, Paige [VerfasserIn] |
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| | Yoshikawa, Yutaka [VerfasserIn] |
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| | Yasui, Hiroyuki [VerfasserIn] |
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| | Karck, Matthias [VerfasserIn] |
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| | Szabó, Gábor [VerfasserIn] |
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| Titel: | Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes |
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| Verf.angabe: | Sevil Korkmaz-Icöz, Ayhan Atmanli, Tamás Radovits, Shiliang Li, Peter Hegedüs, Mihály Ruppert, Paige Brlecic, Yutaka Yoshikawa, Hiroyuki Yasui, Matthias Karck, Gábor Szabó |
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| Jahr: | 2016 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 18.05.2020 ; Published: 23 October 2015 |
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| Titel Quelle: | Enthalten in: The journal of physiological sciences |
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| Ort Quelle: | [Tokyo] : Springer, 2006 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 66(2016), 2, Seite 113-125 |
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| ISSN Quelle: | 1880-6562 |
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| Abstract: | We recently demonstrated that the pre-treatment of rats with zinc and acetylsalicylic acid complex in the form of bis(aspirinato)zinc(II) [Zn(ASA)2] is superior to acetylsalicylic acid in protecting the heart from acute myocardial ischemia. Herein, we hypothesized that Zn(ASA)2 treatment after the onset of an acute myocardial injury could protect the heart. The rats were treated with a vehicle or Zn(ASA)2 after an isoproterenol injection. Isoproterenol-induced cardiac damage [inflammatory infiltration into myocardial tissue, DNA-strand breakage evidenced by TUNEL-assay, increased 11-dehydro thromboxane (TX)B2-levels, elevated ST-segment, widened QRS complex and prolonged QT-interval] was prevented by the Zn(ASA)2 treatment. In isoproterenol-treated rats, load-independent left ventricular contractility parameters were significantly improved after Zn(ASA)2. Furthermore, Zn(ASA)2 significantly increased the myocardial mRNA-expression of superoxide dismutase-1, glutathione peroxidase-4 and decreased the level of Na+/K+/ATPase. Postconditioning with Zn(ASA)2 protects the heart from acute myocardial ischemia. Its mechanisms of action might involve inhibition of pro-inflammatory prostanoids and upregulation of antioxidant enzymes. |
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| DOI: | doi:10.1007/s12576-015-0403-6 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1007/s12576-015-0403-6 |
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| | Volltext: https://jps.biomedcentral.com/articles/10.1007/s12576-015-0403-6 |
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| | DOI: https://doi.org/10.1007/s12576-015-0403-6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1698502753 |
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| Verknüpfungen: | → Zeitschrift |
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Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes / Korkmaz-İçöz, Sevil [VerfasserIn]; 2016 (Online-Ressource)
