Reversal of anticoagulation with dabigatran in an 82-year-old patient with traumatic retroperitoneal arterial bleeding using the new antidote idarucizumab

• Verfasst von: Hofer, Stefan [VerfasserIn]
• Verfasst von: Philipsenburg, Christoph [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Verfasst von: Brenner, Thorsten [VerfasserIn]
• Titel: Reversal of anticoagulation with dabigatran in an 82-year-old patient with traumatic retroperitoneal arterial bleeding using the new antidote idarucizumab
• Titelzusatz: a case report
• Verf.angabe: Stefan Hofer, Christoph Philipsenburg, Markus A. Weigand, Thorsten Brenner
• E-Jahr: 2016
• Jahr: December 1, 2016
• Umfang: 5 S.
• Fussnoten: Gesehen am 19.05.2020
• Titel Quelle: Enthalten in: A&A case reports
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 2013
• Jahr Quelle: 2016
• Band/Heft Quelle: 7(2016), 11, Seite 227-231
• ISSN Quelle: 2325-7237
• DOI: doi:10.1213/XAA.0000000000000395
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1698519389

Abstract

Dabigatran etexilate is a direct oral anticoagulant used for the prevention of stroke in atrial fibrillation. Idarucizumab is a recently approved specific antidote that reverses the effect of dabigatran within minutes. We report the case of an 82-year-old patient with traumatic retroperitoneal arterial bleeding under anticoagulation with dabigatran etexilate. By administration of idarucizumab, we successfully normalized coagulation and saved the patient from an operation. In the course of the disease, a slight reincrease in dabigatran etexilate plasma levels was observed 2 days after the reversal, which could lead to a new onset of bleeding.