Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system

• Verfasst von: Höfer, Thomas [VerfasserIn]
• Verfasst von: Barile, Melania [VerfasserIn]
• Verfasst von: Floßdorf, Michael [VerfasserIn]
• Titel: Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system
• Verf.angabe: Thomas Höfer, Melania Barile, Michael Flossdorf
• E-Jahr: 2016
• Jahr: 20th April 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 19.05.2020
• Titel Quelle: Enthalten in: Current opinion in biotechnology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2016
• Band/Heft Quelle: 39(2016), Seite 150-156
• ISSN Quelle: 1879-0429
• DOI: doi:10.1016/j.copbio.2016.04.001
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1698523157

Abstract

In recent years, sophisticated fate-mapping tools have been developed to study the behavior of stem cells in the intact organism. These experimental approaches are beginning to yield a quantitative picture of how cell numbers are regulated during steady state and in response to challenges. Focusing on hematopoiesis and immune responses, we discuss how novel mathematical approaches driven by these fate-mapping data have provided insights into the dynamics and topology of cellular differentiation pathways in vivo. The combination of experiment and theory has allowed to quantify the degree of self-renewal in stem and progenitor cells, shown how native hematopoiesis differs fundamentally from post-transplantation hematopoiesis, and uncovered that the diversification of T lymphocytes during immune responses resembles tissue renewal driven by stem cells.