| |  Online-Ressource |
|---|
| Verfasst von: | Kornprobst, Markus [VerfasserIn]  |
|---|
| | Turk, Martin [VerfasserIn] |
|---|
| | Kellner, Nikola [VerfasserIn] |
|---|
| | Cheng, Jingdong [VerfasserIn] |
|---|
| | Flemming, Dirk [VerfasserIn] |
|---|
| | Koš-Braun, Isabelle C. [VerfasserIn] |
|---|
| | Koš, Martin [VerfasserIn] |
|---|
| | Thoms, Matthias [VerfasserIn] |
|---|
| | Berninghausen, Otto [VerfasserIn] |
|---|
| | Beckmann, Roland [VerfasserIn] |
|---|
| | Hurt, Ed [VerfasserIn] |
|---|
| Titel: | Architecture of the 90S pre-ribosome |
|---|
| Titelzusatz: | a structural view on the birth of the eukaryotic ribosome |
|---|
| Verf.angabe: | Markus Kornprobst, Martin Turk, Nikola Kellner, Jingdong Cheng, Dirk Flemming, Isabelle Koš-Braun, Martin Koš, Matthias Thoms, Otto Berninghausen, Roland Beckmann, and Ed Hurt |
|---|
| E-Jahr: | 2016 |
|---|
| Jahr: | 14 July 2016 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 19.05.2020 |
|---|
| Titel Quelle: | Enthalten in: Cell |
|---|
| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
|---|
| Jahr Quelle: | 2016 |
|---|
| Band/Heft Quelle: | 166(2016), 2, Seite 380-393 |
|---|
| ISSN Quelle: | 1097-4172 |
|---|
| Abstract: | The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional ribosome formation, composed of ∼70 assembly factors and several small nucleolar RNAs (snoRNAs) that associate with nascent pre-rRNA. We report the cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome, revealing how a network of biogenesis factors including 19 β-propellers and large α-solenoid proteins engulfs the pre-rRNA. Within the 90S pre-ribosome, we identify the UTP-A, UTP-B, Mpp10-Imp3-Imp4, Bms1-Rcl1, and U3 snoRNP modules, which are organized around 5′-ETS and partially folded 18S rRNA. The U3 snoRNP is strategically positioned at the center of the 90S particle to perform its multiple tasks during pre-rRNA folding and processing. The architecture of the elusive 90S pre-ribosome gives unprecedented structural insight into the early steps of pre-rRNA maturation. Nascent rRNA that is co-transcriptionally folded and given a particular shape by encapsulation within a dedicated mold-like structure is reminiscent of how polypeptides use chaperone chambers for their protein folding. |
|---|
| DOI: | doi:10.1016/j.cell.2016.06.014 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2016.06.014 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0092867416307437 |
|---|
| | DOI: https://doi.org/10.1016/j.cell.2016.06.014 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1698560184 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Architecture of the 90S pre-ribosome / Kornprobst, Markus [VerfasserIn]; 14 July 2016 (Online-Ressource)
