Distinct types of feeding related neurons in mouse hypothalamus

• Verfasst von: Tang, Yan [VerfasserIn]
• Verfasst von: Benusiglio, Diego [VerfasserIn]
• Verfasst von: Grinevich, Valéry [VerfasserIn]
• Verfasst von: Lin, Longnian [VerfasserIn]
• Titel: Distinct types of feeding related neurons in mouse hypothalamus
• Verf.angabe: Yan Tang, Diego Benusiglio, Valery Grinevich and Longnian Lin
• E-Jahr: 2016
• Jahr: [18 May 2016]
• Umfang: ? S.
• Illustrationen: Diagramme
• Fussnoten: Gesehen am 20.05.2020
• Titel Quelle: Enthalten in: Frontiers in behavioral neuroscience
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2016
• Band/Heft Quelle: 10(2016)
• ISSN Quelle: 1662-5153
• DOI: doi:10.3389/fnbeh.2016.00091
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Feeding Behavior
• Sach-SW: feeding-related neurons
• Sach-SW: firing patterns
• Sach-SW: food intake
• Sach-SW: Hypothalamus
• Sach-SW: in vivo multi-channel recording
• K10plus-PPN: 1698606591

Abstract

The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothalamus and their feeding behavior. Using tetrode-based in vivo recording technique, we identified various firing patterns of hypothalamic FRNs, which, after the initiation of food intake, can be sorted into four types: sharp increase (type I), slow increase (type II), sharp decrease (type III) and sustained decrease (type IV) of firing rates. The feeding-related firing response of FRNs was rigidly related to the duration of food intake and, to a less extent, associated with the type of food. The majority of these FRNs responded to glucose and leptin and exhibited electrophysiological characteristics of putative GABAergic neurons. In conclusion, our study demonstrated the diversity of neurons in the complex hypothalamic network coordinating food intake.