Increased hippocampal CD38 and systemic inflammation after partial hepatectomy does not induce impairment of spatial cognition

• Verfasst von: Schnitzler, Sebastian [VerfasserIn]
• Verfasst von: Kopitz, Jürgen [VerfasserIn]
• Verfasst von: Plaschke, Konstanze [VerfasserIn]
• Titel: Increased hippocampal CD38 and systemic inflammation after partial hepatectomy does not induce impairment of spatial cognition
• Verf.angabe: Sebastian Schnitzler, Jürgen Kopitz, Konstanze Plaschke
• E-Jahr: 2016
• Jahr: 11 Oct 2016
• Umfang: 8 S.
• Fussnoten: Gesehen am 20.05.2020
• Titel Quelle: Enthalten in: Neurological research
• Ort Quelle: Abingdon, Oxon : Taylor & Francis, 1979
• Jahr Quelle: 2016
• Band/Heft Quelle: 38(2016), 11, Seite 973-980
• ISSN Quelle: 1743-1328
• DOI: doi:10.1080/01616412.2016.1242452
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CD38
• Sach-SW: cognition
• Sach-SW: inflammation
• Sach-SW: sevoflurane anaesthesia
• Sach-SW: surgery
• K10plus-PPN: 1698643020

Abstract

The role of inflammation in cognitive alterations in a post-operative setting is still not fully understood. Surgical interventions can cause systemic inflammations which eventually can induce neuroinflammation. However, the main causes of functional changes after surgery are still elusive. In this study, we investigated the role of CD38, a TNFα-inducible NADH+ cyclase and hydrolase. We assume that CD38 overexpression impairs mitochondrial ATP synthesis. Within the hippocampus, the resulting cellular death could lead to cognitive impairment.