Online-Ressource | |
Verfasst von: | Berger, Marc Moritz [VerfasserIn] |
Köhne, Hannah [VerfasserIn] | |
Hotz, Lorenz [VerfasserIn] | |
Hammer, Moritz [VerfasserIn] | |
Schommer, Kai [VerfasserIn] | |
Bärtsch, Peter [VerfasserIn] | |
Mairbäurl, Heimo [VerfasserIn] | |
Titel: | Remote ischemic preconditioning delays the onset of acute mountain sickness in normobaric hypoxia |
Verf.angabe: | Marc M. Berger, Hannah Köhne, Lorenz Hotz, Moritz Hammer, Kai Schommer, Peter Bärtsch & Heimo Mairbäurl |
E-Jahr: | 2015 |
Jahr: | 5 March 2015 |
Fussnoten: | Gesehen am 22.05.2020 |
Titel Quelle: | Enthalten in: Physiological reports |
Ort Quelle: | [S.l.] : Wiley, 2013 |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 3(2015,3) Artikel-Nummer e12325, 9 Seiten |
ISSN Quelle: | 2051-817X |
Abstract: | Acute mountain sickness (AMS) is a neurological disorder occurring when ascending too fast, too high. Remote ischemic preconditioning (RIPC) is a noninvasive intervention protecting remote organs from subsequent hypoxic damage. We hypothesized that RIPC protects against AMS and that this effect is related to reduced oxidative stress. Fourteen subjects were exposed to 18 hours of normoxia (21% oxygen) and 18 h of normobaric hypoxia (12% oxygen, equivalent to 4500 m) on different days in a blinded, randomized order. RIPC consisted of four cycles of lower limb ischemia (5 min) and 5 min of reperfusion, and was performed immediately before the study room was entered. A control group was exposed to hypoxia (12% oxygen, n = 14) without RIPC. AMS was evaluated by the Lake Louise score (LLS) and the AMS-C score of the Environmental Symptom Questionnaire. Plasma concentrations of ascorbate radicals, oxidized sulfhydryl (SH) groups, and electron paramagnetic resonance (EPR) signal intensity were measured as biomarkers of oxidative stress. RIPC reduced AMS scores (LLS: 1.9 ± 0.4 vs. 3.2 ± 0.5; AMS-C score: 0.4 ± 0.1 vs. 0.8 ± 0.2), ascorbate radicals (27 ± 7 vs. 65 ± 18 nmol/L), oxidized SH groups (3.9 ± 1.4 vs. 14.3 ± 4.6 μmol/L), and EPR signal intensity (0.6 ± 0.2 vs. 1.5 ± 0.4 × 106) after 5 h in hypoxia (all P < 0.05). After 18 hours in hypoxia there was no difference in AMS and oxidative stress between RIPC and control. AMS and plasma markers of oxidative stress did not correlate. This study demonstrates that RIPC transiently reduces symptoms of AMS and that this effect is not associated with reduced plasma levels of reactive oxygen species. |
DOI: | doi:10.14814/phy2.12325 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext ; Verlag: https://doi.org/10.14814/phy2.12325 |
Volltext: https://physoc.onlinelibrary.wiley.com/doi/abs/10.14814/phy2.12325 | |
DOI: https://doi.org/10.14814/phy2.12325 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | AMS |
high altitude | |
oxidative stress | |
prevention | |
reactive oxygen species | |
K10plus-PPN: | 1698680252 |
Verknüpfungen: | → Zeitschrift |