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Verfasst von:Düzova, Ali [VerfasserIn]   i
 Kirchner, Marietta [VerfasserIn]   i
 Schaefer, Franz [VerfasserIn]   i
 Wühl, Elke [VerfasserIn]   i
Titel:Isolated nocturnal and isolated daytime hypertension associate with altered cardiovascular morphology and function in children with chronic kidney disease
Titelzusatz:findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease study
Verf.angabe:Ali Düzova, Aysun Karabay Bayazit, Nur Canpolat, Anna Niemirska, Ipek Kaplan Bulut, Karolis Azukaitis, Tevfik Karagoz, Berna Oguz, Sevcan Erdem, Ali Anarat, Bruno Ranchin, Rukshana Shroff, Milan Djukic, Jerome Harambat, Alev Yilmaz, Nurdan Yildiz, Birsin Ozcakar, Anja Büscher, Francesca Lugani, Simone Wygoda, Sibylle Tschumi, Ariane Zaloszyc, Augustina Jankauskiene, Guido Laube, Matthias Galiano, Marietta Kirchner, Uwe Querfeld, Anette Melk, Franz Schaefer, Elke Wühl, for the 4C Study Consortium
E-Jahr:2019
Jahr:November 2019
Umfang:9 S.
Fussnoten:Gesehen am 25.05.2020
Titel Quelle:Enthalten in: Journal of hypertension
Ort Quelle:London : Lippincott, Williams & Wilkins, 1983
Jahr Quelle:2019
Band/Heft Quelle:37(2019), 11, Seite 2247-2255
ISSN Quelle:1473-5598
Abstract:Introduction: Prevalence of isolated nocturnal hypertension (INH) and isolated daytime hypertension (IDH) is around 10% in adults. Data in children, especially in chronic kidney disease (CKD), are lacking. The aim of this cross-sectional multicenter cohort study was to define the prevalence of INH and IDH and its association with cardiovascular morphology and function, that is, pulse wave velocity (PWV), carotid intima-media thickness (cIMT), or left ventricular mass index (LVMI) in children with CKD. Methods: Ambulatory blood pressure (BP) monitoring profiles were analyzed in 456 children with CKD stages III-V participating in the Cardiovascular Comorbidity in Children with Chronic Kidney Disease Study (64.3% males, 71.3% congenital anomaly of the kidney and urinary tract, age 12.5 ± 3.2 years, estimated glomerular filtration rate 29 ± 12 ml/min per 1.73 m2). Baseline PWV, cIMT, and LVMI were compared in normotension, INH, IDH, or sustained 24-h hypertension. Results: Prevalence of sustained hypertension was 18.4%, of INH 13.4%, and of IDH 3.7%. PWV SDS (SD score) and cIMT SDS were significantly higher in sustained hypertension and INH, and PWV SDS was significantly higher in IDH, compared with normotension. LVMI was significantly increased in sustained hypertension, but not in INH or IDH. Determinants of INH were smallness for gestational age, older age, higher height SDS and parathyroid hormone, and shorter duration of CKD. In logistic regression analysis, day/night-time hypertension or ambulatory BP monitoring pattern (normal, INH, IDH, sustained hypertension) were independently associated with cardiovascular outcome measures: elevated night-time BP was associated with increased cIMT, PWV, and left ventricular hypertrophy; INH was associated with cIMT. Conclusion: INH is present in almost one out of seven children with predialysis CKD; INH and nocturnal hypertension in general are associated with alterations of arterial morphology and function.
DOI:doi:10.1097/HJH.0000000000002160
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/HJH.0000000000002160
 Volltext: https://journals.lww.com/jhypertension/Abstract/2019/11000/Isolated_nocturnal_and_isolated_daytime.18.aspx
 DOI: https://doi.org/10.1097/HJH.0000000000002160
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1698715994
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