Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice

• Verfasst von: Ang, Gauri [VerfasserIn]
• Verfasst von: McKillop, Laura E. [VerfasserIn]
• Verfasst von: Purple, Ross [VerfasserIn]
• Verfasst von: Blanco-Duque, Cristina [VerfasserIn]
• Verfasst von: Peirson, Stuart N. [VerfasserIn]
• Verfasst von: Foster, Russell G. [VerfasserIn]
• Verfasst von: Harrison, Paul J. [VerfasserIn]
• Verfasst von: Sprengel, Rolf [VerfasserIn]
• Verfasst von: Davies, Kay E. [VerfasserIn]
• Verfasst von: Oliver, Peter L. [VerfasserIn]
• Verfasst von: Bannerman, David M. [VerfasserIn]
• Verfasst von: Vyazovskiy, Vladyslav V. [VerfasserIn]
• Titel: Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice
• Titelzusatz: relevance to neuropsychiatric disorders
• Verf.angabe: Gauri Ang, Laura E. McKillop, Ross Purple, Cristina Blanco-Duque, Stuart N. Peirson, Russell G. Foster, Paul J. Harrison, Rolf Sprengel, Kay E. Davies, Peter L. Oliver, David M. Bannerman and Vladyslav V. Vyazovskiy
• E-Jahr: 2018
• Jahr: 14 August 2018
• Umfang: 14 S.
• Fussnoten: Gesehen am 26.05.2020
• Titel Quelle: Enthalten in: Translational Psychiatry
• Ort Quelle: London : Nature Publishing Group, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018), Artikel-ID 154, Seite 1-14
• ISSN Quelle: 2158-3188
• DOI: doi:10.1038/s41398-018-0199-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1698841175

Abstract

Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Gria1−/− mice exhibit a phenotype relevant for neuropsychiatric disorders, including reduced synaptic plasticity and, at the behavioural level, attentional deficits leading to aberrant salience. In this study we report a striking reduction of EEG power density including the spindle-frequency range (10-15 Hz) during sleep in Gria1−/− mice. The reduction of spindle-activity in Gria1−/− mice was accompanied by longer REM sleep episodes, increased EEG slow-wave activity in the occipital derivation during baseline sleep, and a reduced rate of decline of EEG slow wave activity (0.5-4 Hz) during NREM sleep after sleep deprivation. These data provide a novel link between glutamatergic dysfunction and sleep abnormalities in a schizophrenia-relevant mouse model.