Status: Bibliographieeintrag
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| Verfasst von: | Angeles, Arlou Kristina J. [VerfasserIn]  |
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| | Bauer, Simone [VerfasserIn] |
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| | Ratz, Leonie [VerfasserIn] |
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| | Klauck, Sabine [VerfasserIn] |
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| | Sültmann, Holger [VerfasserIn] |
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| Titel: | Genome-based classification and therapy of prostate cancer |
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| Verf.angabe: | Arlou Kristina Angeles, Simone Bauer, Leonie Ratz, Sabine M. Klauck and Holger Sültmann |
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| E-Jahr: | 2018 |
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| Jahr: | 2 September 2018 |
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| Umfang: | 26 S. |
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| Fussnoten: | Gesehen am 26.05.2020 |
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| Titel Quelle: | Enthalten in: Diagnostics |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 8(2018,3) Artikel-Nummer 62, 26 Seiten |
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| ISSN Quelle: | 2075-4418 |
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| Abstract: | In the past decade, multi-national and multi-center efforts were launched to sequence prostate cancer genomes, transcriptomes, and epigenomes with the aim of discovering the molecular underpinnings of tumorigenesis, cancer progression, and therapy resistance. Multiple biological markers and pathways have been discovered to be tumor drivers, and a molecular classification of prostate cancer is emerging. Here, we highlight crucial findings of these genome-sequencing projects in localized and advanced disease. We recapitulate the utility and limitations of current clinical practices to diagnosis, prognosis, and therapy, and we provide examples of insights generated by the molecular profiling of tumors. Novel treatment concepts based on these molecular alterations are currently being addressed in clinical trials and will lead to an enhanced implementation of precision medicine strategies. |
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| DOI: | doi:10.3390/diagnostics8030062 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/diagnostics8030062 |
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| | Volltext: https://www.mdpi.com/2075-4418/8/3/62 |
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| | DOI: https://doi.org/10.3390/diagnostics8030062 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | copy number alterations |
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| | genomics |
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| | molecular markers |
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| | mutations |
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| | patient stratification |
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| | precision medicine |
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| | prostate cancer |
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| K10plus-PPN: | 1698845693 |
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| Verknüpfungen: | → Zeitschrift |
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Genome-based classification and therapy of prostate cancer / Angeles, Arlou Kristina J. [VerfasserIn]; 2 September 2018 (Online-Ressource)
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