| |  Online-Ressource |
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| Verfasst von: | Hampölz, Bernhard [VerfasserIn]  |
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| | Schwarz, Andre [VerfasserIn] |
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| | Ronchi, Paolo [VerfasserIn] |
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| | Bragulat-Teixidor, Helena [VerfasserIn] |
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| | Tischer, Christian [VerfasserIn] |
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| | Gaspar, Imre [VerfasserIn] |
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| | Ephrussi, Anne [VerfasserIn] |
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| | Schwab, Yannick [VerfasserIn] |
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| | Beck, Martin [VerfasserIn] |
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| Titel: | Nuclear pores assemble from nucleoporin condensates during oogenesis |
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| Verf.angabe: | Bernhard Hampoelz, Andre Schwarz, Paolo Ronchi, Helena Bragulat-Teixidor, Christian Tischer, Imre Gaspar, Anne Ephrussi, Yannick Schwab, and Martin Beck |
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| E-Jahr: | 2019 |
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| Jahr: | 17 October 2019 |
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| Umfang: | 34 S. |
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| Fussnoten: | Gesehen am 28.05.2020 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 179(2019), 3, Seite 671-686.e17 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | The molecular events that direct nuclear pore complex (NPC) assembly toward nuclear envelopes have been conceptualized in two pathways that occur during mitosis or interphase, respectively. In gametes and embryonic cells, NPCs also occur within stacked cytoplasmic membrane sheets, termed annulate lamellae (AL), which serve as NPC storage for early development. The mechanism of NPC biogenesis at cytoplasmic membranes remains unknown. Here, we show that during Drosophila oogenesis, Nucleoporins condense into different precursor granules that interact and progress into NPCs. Nup358 is a key player that condenses into NPC assembly platforms while its mRNA localizes to their surface in a translation-dependent manner. In concert, Microtubule-dependent transport, the small GTPase Ran and nuclear transport receptors regulate NPC biogenesis in oocytes. We delineate a non-canonical NPC assembly mechanism that relies on Nucleoporin condensates and occurs away from the nucleus under conditions of cell cycle arrest. |
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| DOI: | doi:10.1016/j.cell.2019.09.022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cell.2019.09.022 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0092867419310736 |
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| | DOI: https://doi.org/10.1016/j.cell.2019.09.022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | local translation |
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| | microtubule-dependent transport |
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| | NPC assembly |
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| | nuclear pore complex |
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| | nucleoporin condensation |
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| | Nup358 |
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| | oogenesis |
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| | Ran |
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| | RNA localization |
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| K10plus-PPN: | 1698940319 |
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| Verknüpfungen: | → Zeitschrift |
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Nuclear pores assemble from nucleoporin condensates during oogenesis / Hampölz, Bernhard [VerfasserIn]; 17 October 2019 (Online-Ressource)
