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Verfasst von:Breckwoldt, Michael O. [VerfasserIn]   i
 Stock, Christian [VerfasserIn]   i
 Xia, Annie [VerfasserIn]   i
 Heckel, Andreas [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Pham, Mirko [VerfasserIn]   i
 Heiland, Sabine [VerfasserIn]   i
 Bäumer, Philipp [VerfasserIn]   i
Titel:Diffusion tensor imaging adds diagnostic accuracy in magnetic resonance neurography
Verf.angabe:Breckwoldt, MD, PhD, Christian Stock, PhD, MSc, Annie Xia, Andreas Heckel, MD, MSc, Martin Bendszus, MD, Mirko Pham, MD, Sabine Heiland, PhD, and Philipp Bäumer, MD, MSc
E-Jahr:2015
Jahr:February 18, 2015
Umfang:7 S.
Fussnoten:Gesehen am 28.05.2020
Titel Quelle:Enthalten in: Investigative radiology
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1966
Jahr Quelle:2015
Band/Heft Quelle:50(2015), 8, Seite 498-504
ISSN Quelle:1536-0210
Abstract:Objective - The aim of this study was to determine whether quantitative diffusion tensor imaging (DTI) adds diagnostic accuracy in magnetic resonance neurography. - Materials and Methods - This prospective study was approved by the institutional review board. We enrolled 16 patients with peripheral polyneuropathy of various etiologies involving the upper arm and 30 healthy controls. Magnetic resonance neurography was performed at 3 T using transverse T2-weighted (T2-w) turbo spin echo and spin echo planar imaging diffusion-weighted sequences. T2-weighted normalized signal (nT2), fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial diffusivity (RD), and axial diffusivity (AD) of the median, ulnar, and radial nerves were quantified after manual segmentation. Diagnostic performance of each separate parameter and combinations of parameters was assessed using the area under the receiver operating characteristic curve (AUC). Bootstrap validation was used to adjust for potential overfitting. - Results - Average nT2, ADC, RD, and AD values of the median, ulnar, and radial nerve were significantly increased in neuropathy patients compared with that in healthy controls (nT2, 1.49 ± 0.05 vs 1.05 ± 0.05; ADC, 1.4 × 10−3 ± 2.8 × 10−5 mm2/s vs 1.1 × 10−3 ± 1.3 × 10−5 mm2/s; RD, 9.5 × 10−4 ± 2.9 × 10−5 mm2/s vs 7.2 × 10−4 ± 1.3 × 10−5 mm2/s; AD, 2.3 × 10−3 ± 3.7 × 10−5 mm2/s vs 2.0 × 10−3 ± 2.2 × 10−5 mm2/s; P < 0.001 for all comparisons). Fractional anisotropy values were significantly decreased in patients (0.51 ± 0.01 vs 0.59 ± 0.01; P < 0.001). T2-weighted normalized signal and DTI parameters had comparable diagnostic accuracy (adjusted AUC: T2-w, 0.92; FA, 0.88; ADC, 0.89; AD, 0.84; RD, 0.86). Combining DTI parameters significantly improved the diagnostic accuracy over single-parameter analysis. In addition, the combination of nT2 with DTI parameters yielded excellent adjusted AUCs up to 0.97 (nT2 + FA). - Conclusions - Diffusion tensor imaging has high diagnostic accuracy in peripheral neuropathy. Combining DTI with T2 can outperform T2-w imaging alone and provides added value in magnetic resonance neurography.
DOI:doi:10.1097/RLI.0000000000000156
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/RLI.0000000000000156
 Volltext: https://journals.lww.com/investigativeradiology/fulltext/2015/08000/Diffusion_Tensor_Imaging_Adds_Diagnostic_Accuracy.5. ...
 DOI: https://doi.org/10.1097/RLI.0000000000000156
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1698953526
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