Local and distant input controlling excitation in layer II of the medial entorhinal cortex

• Verfasst von: Fuchs, Elke C. [VerfasserIn]
• Verfasst von: Neitz, Angela [VerfasserIn]
• Verfasst von: Pinna, Roberta [VerfasserIn]
• Verfasst von: Melzer, Sarah [VerfasserIn]
• Verfasst von: Caputi, Antonio [VerfasserIn]
• Verfasst von: Monyer, Hannah [VerfasserIn]
• Titel: Local and distant input controlling excitation in layer II of the medial entorhinal cortex
• Verf.angabe: Elke C. Fuchs, Angela Neitz, Roberta Pinna, Sarah Melzer, Antonio Caputi, and Hannah Monyer
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 15 S.
• Fussnoten: Published: December 17, 2015 ; Gesehen am 28.05.2020
• Titel Quelle: Enthalten in: Neuron
• Ort Quelle: [Cambridge, Mass.] : Cell Press, 1988
• Jahr Quelle: 2016
• Band/Heft Quelle: 89(2016), 1, Seite 194-208
• ISSN Quelle: 1097-4199
• DOI: doi:10.1016/j.neuron.2015.11.029
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1698954832

Abstract

Layer II (LII) of the medial entorhinal cortex (MEC) comprises grid cells that support spatial navigation. The firing pattern of grid cells might be explained by attractor dynamics in a network, which requires either direct excitatory connectivity between phase-specific grid cells or indirect coupling via interneurons. However, knowledge regarding local networks that support in vivo activity is incomplete. Here we identified essential components of LII networks in the MEC. We distinguished four types of excitatory neurons that exhibit cell-type-specific local excitatory and inhibitory connectivity. Furthermore, we found that LII neurons contribute to the excitation of contralateral neurons in the corresponding layer. Finally, we demonstrated that the medial septum controls excitation in the MEC via two subpopulations of long-range GABAergic neurons that target distinct interneurons in LII, thereby disinhibiting local circuits. We thus identified local connections that could support attractor dynamics and external inputs that likely govern excitation in LII.