Co-activation of cultured human natural killer cells

• Verfasst von: Urlaub, Doris [VerfasserIn]
• Verfasst von: Bhat, Rauf Ahmed [VerfasserIn]
• Verfasst von: Messmer, Birgitta [VerfasserIn]
• Verfasst von: Watzl, Carsten [VerfasserIn]
• Titel: Co-activation of cultured human natural killer cells
• Titelzusatz: enhanced function and decreased inhibition
• Verf.angabe: Doris Urlaub, Rauf Bhat, Birgitta Messmer, and Carsten Watzl
• E-Jahr: 2016
• Jahr: [2016]
• Umfang: 7 S.
• Illustrationen: Diagramme
• Fussnoten: Gesehen am 29.05.2020
• Titel Quelle: Enthalten in: Journal of toxicology and environmental health / A
• Ort Quelle: London [u.a.] : Taylor & Francis Corp., 1998
• Jahr Quelle: 2016
• Band/Heft Quelle: 79(2016), 22-23, Seite 1078-1084
• ISSN Quelle: 2381-3504
• DOI: doi:10.1080/15287394.2016.1219587
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1699052360

Abstract

Natural killer (NK) cells are important immune effector cells that protect the organism against viral infections and cancer. The cytotoxic activity of NK cells is induced by the engagement of a number of different activating surface receptors and controlled by inhibitory receptors to ensure self-tolerance. Resting NK cells need to be co-activated by involvement of at least two distinct activating receptors in order to induce their functional activity. However, in cultured NK cells, which have been expanded in cytokines such as interleukin (IL)-2, the engagement of a single activating receptor may be sufficient to induce their function. Data demonstrated that also cultured NK cells may be co-activated by involvement of certain combinations of activating receptors. This co-activation results in enhanced activation of Vav-1 and ERK signaling pathways and produces greater degranulation. In addition to enhanced functionality, co-activation makes NK cells more resistant to the effect of inhibitory receptors, thereby inducing more potent and efficient NK cell responses.