Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Löffers, Christine [VerfasserIn]   i
 Heilig, Bernhard [VerfasserIn]   i
 Hecker, Markus [VerfasserIn]   i
Titel:T-786C single nucleotide polymorphism of the endothelial nitric oxide synthase gene as a risk factor for endothelial dysfunction in polymyalgia rheumatica
Verf.angabe:Christine Löffers, Bernhard Heilig, Markus Hecker
E-Jahr:2015
Jahr:27 August 2015
Umfang:5 S.
Fussnoten:Gesehen am 02.06.2020
Titel Quelle:Enthalten in: Clinical and experimental rheumatology
Ort Quelle:Pisa, 1999
Jahr Quelle:2015
Band/Heft Quelle:33(2015), 5, Seite 726-730
ISSN Quelle:1593-098X
Abstract:OBJECTIVES: We investigated the association of the T-786C single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase gene (NOS3), which is characterised by reduced expression of the enzyme in response to shear stress or interleukin-10 stimulation and significantly associated with coronary heart disease or rheumatoid arthritis, with the occurrence of isolated polymyalgia rheumatica. - METHODS: A cohort of 78 patients who had presented at a rheumatological specialist practice in Heidelberg was tested for the T-786C SNP by means of restriction fragment length polymorphism analysis, and the result was compared with the data of a control cohort (n=2061) compiled from the genotyping of umbilical cord arteries from newborns. Patients were tested for an association with the genotype and their clinical characteristics obtained at the time of the initial presentation and during the first year of treatment. - RESULTS: The T-786C SNP of the NOS3 gene was significantly associated with isolated PMR (p=0.0009; OR 2.475). The C-allele frequency in patients with PMR was higher than in patients with rheumatoid arthritis, who also showed a significant association with the T-786C SNP (PMR 0.481 vs. 0.422 RA). A significant association with clinical features of the patients could not be detected. - CONCLUSIONS: The T-786C SNP of the NOS3 gene, which predisposes towards the development of endothelial dysfunction, is significantly associated with polymyalgia rheumatica manifesting itself without any clinically detectable vascular involvement.
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://pubmed.ncbi.nlm.nih.gov/26314610/
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Case-Control Studies
 Endothelium, Vascular
 Female
 Gene Frequency
 Genetic Association Studies
 Genetic Predisposition to Disease
 Germany
 Humans
 Male
 Middle Aged
 Nitric Oxide Synthase Type III
 Phenotype
 Polymorphism, Single Nucleotide
 Polymyalgia Rheumatica
 Risk Factors
K10plus-PPN:1699093989
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68582527   QR-Code
zum Seitenanfang