Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits

• Verfasst von: Freudenberg, Florian [VerfasserIn]
• Verfasst von: Resnik, Evgeny [VerfasserIn]
• Verfasst von: Kolleker, Alexander [VerfasserIn]
• Verfasst von: Celikel, Tansu [VerfasserIn]
• Verfasst von: Sprengel, Rolf [VerfasserIn]
• Verfasst von: Seeburg, Peter H. [VerfasserIn]
• Titel: Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits
• Verf.angabe: Florian Freudenberg, Evgeny Resnik, Alexander Kolleker, Tansu Celikel, Rolf Sprengel, Peter H. Seeburg
• E-Jahr: 2016
• Jahr: 11 July 2016
• Umfang: 8 S.
• Fussnoten: Im Titel sind ''-'' und "/" hochgestellt ; Gesehen am 03.06.2020
• Titel Quelle: Enthalten in: Neurobiology of learning and memory
• Ort Quelle: Orlando, Fla. : Academic Press, 1995
• Jahr Quelle: 2016
• Band/Heft Quelle: 135(2016), Seite 83-90
• ISSN Quelle: 1095-9564
• DOI: doi:10.1016/j.nlm.2016.07.005
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adeno-associated virus
• Sach-SW: GluR-A
• Sach-SW: GluR1
• Sach-SW: Mouse
• Sach-SW: Viral gene transfer
• K10plus-PPN: 1699282498

Abstract

Spatial working memory (SWM) is an essential cognitive function important for survival in a competitive environment. In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1−/− mice). Here we used viral gene transfer to show that re-expression of GluA1 in the hippocampus can affect the behavioral performance of GluA1 deficient mice. We found that Gria1−/− mice with hippocampus-specific rescue of GluA1 expression (Gria1Hpc mice) are more anxious, less hyperactive and only partly impaired in SWM expression in the Y-maze spatial novelty preference paradigm compared to Gria1−/− mice. However, Gria1Hpc mice still express SWM performance deficits when tested in the rewarded alternation T-maze task. Thus, the restoration of hippocampal function affects several behaviors of GluA1 deficient mice - including SWM expression - in different tasks. The virus-mediated GluA1 expression in Gria1−/− mice is not sufficient for a comprehensive SWM restoration, suggesting that both hippocampal as well as extra-hippocampal GluA1-containing AMPA receptors contribute to SWM.