Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Freudenberg, Florian [VerfasserIn]  |
| Resnik, Evgeny [VerfasserIn]  |
| Kolleker, Alexander [VerfasserIn]  |
| Celikel, Tansu [VerfasserIn]  |
| Sprengel, Rolf [VerfasserIn]  |
| Seeburg, Peter H. [VerfasserIn]  |
Titel: | Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits |
Verf.angabe: | Florian Freudenberg, Evgeny Resnik, Alexander Kolleker, Tansu Celikel, Rolf Sprengel, Peter H. Seeburg |
E-Jahr: | 2016 |
Jahr: | 11 July 2016 |
Umfang: | 8 S. |
Fussnoten: | Im Titel sind ''-'' und "/" hochgestellt ; Gesehen am 03.06.2020 |
Titel Quelle: | Enthalten in: Neurobiology of learning and memory |
Ort Quelle: | Orlando, Fla. : Academic Press, 1995 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 135(2016), Seite 83-90 |
ISSN Quelle: | 1095-9564 |
Abstract: | Spatial working memory (SWM) is an essential cognitive function important for survival in a competitive environment. In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1−/− mice). Here we used viral gene transfer to show that re-expression of GluA1 in the hippocampus can affect the behavioral performance of GluA1 deficient mice. We found that Gria1−/− mice with hippocampus-specific rescue of GluA1 expression (Gria1Hpc mice) are more anxious, less hyperactive and only partly impaired in SWM expression in the Y-maze spatial novelty preference paradigm compared to Gria1−/− mice. However, Gria1Hpc mice still express SWM performance deficits when tested in the rewarded alternation T-maze task. Thus, the restoration of hippocampal function affects several behaviors of GluA1 deficient mice - including SWM expression - in different tasks. The virus-mediated GluA1 expression in Gria1−/− mice is not sufficient for a comprehensive SWM restoration, suggesting that both hippocampal as well as extra-hippocampal GluA1-containing AMPA receptors contribute to SWM. |
DOI: | doi:10.1016/j.nlm.2016.07.005 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.nlm.2016.07.005 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S1074742716301058 |
| DOI: https://doi.org/10.1016/j.nlm.2016.07.005 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adeno-associated virus |
| GluR-A |
| GluR1 |
| Mouse |
| Viral gene transfer |
K10plus-PPN: | 1699282498 |
Verknüpfungen: | → Zeitschrift |
Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits / Freudenberg, Florian [VerfasserIn]; 11 July 2016 (Online-Ressource)
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