Spinal excitatory mechanisms of pathological pain

• Verfasst von: Kuner, Rohini [VerfasserIn]
• Titel: Spinal excitatory mechanisms of pathological pain
• Verf.angabe: Rohini Kuner
• E-Jahr: 2015
• Jahr: April 2015
• Umfang: 7 S.
• Fussnoten: Gesehen am 03.06.2020
• Titel Quelle: Enthalten in: Pain
• Ort Quelle: New York, NY [u.a.] : Lippincott Williams and Wilkins, 1975
• Jahr Quelle: 2015
• Band/Heft Quelle: 156(2015), 4, Seite S11-S17
• ISSN Quelle: 1872-6623
• DOI: doi:10.1097/j.pain.0000000000000118
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1699292701

Abstract

An important property of the nociceptive system is its plasticity, ie, the ability to change in an experience-dependent manner, which is implicated in the transition from acute pain to chronic pathological pain. Disease-induced plasticity can occur at both structural and functional levels and manifests as changes in individual molecules, synapses, cellular function, and network activity. In this short review, the author discusses how synaptic plasticity may mediate pathophysiological alterations linked to chronic pain by virtue of shifting the balance between excitation and inhibition, with a particular emphasis on the spinal dorsal horn.