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| Verfasst von: | Lin, Clara S. [VerfasserIn]  |
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| | Uboldi, Alessandro D. [VerfasserIn] |
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| | Epp, Christian [VerfasserIn] |
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| | Bujard, Hermann [VerfasserIn] |
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| | Tsuboi, Takafumi [VerfasserIn] |
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| | Czabotar, Peter E. [VerfasserIn] |
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| | Cowman, Alan F. [VerfasserIn] |
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| Titel: | Multiple plasmodium falciparum merozoite surface protein 1 complexes mediate merozoite binding to human erythrocytes |
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| Verf.angabe: | Clara S. Lin, Alessandro D. Uboldi, Christian Epp, Hermann Bujard, Takafumi Tsuboi, Peter E. Czabotar, and Alan F. Cowman |
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| E-Jahr: | 2016 |
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| Jahr: | April 1, 2016 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 03.06.2020 |
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| Titel Quelle: | Enthalten in: The journal of biological chemistry |
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| Ort Quelle: | Bethesda, Md. : Soc., 1905 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 291(2016), 14, Seite 7703-7715 |
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| ISSN Quelle: | 1083-351X |
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| Abstract: | Successful invasion of human erythrocytes byPlasmodium falciparummerozoites is required for infection of the host and parasite survival. The early stages of invasion are mediated via merozoite surface proteins that interact with human erythrocytes. The nature of these interactions are currently not well understood, but it is known that merozoite surface protein 1 (MSP1) is critical for successful erythrocyte invasion. Here we show that the peripheral merozoite surface proteins MSP3, MSP6, MSPDBL1, MSPDBL2, and MSP7 bind directly to MSP1, but independently of each other, to form multiple forms of the MSP1 complex on the parasite surface. These complexes have overlapping functions that interact directly with human erythrocytes. We also show that targeting the p83 fragment of MSP1 using inhibitory antibodies inhibits all forms of MSP1 complexes and disrupts parasite growthin vitro. |
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| DOI: | doi:10.1074/jbc.M115.698282 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1074/jbc.M115.698282 |
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| | DOI: https://doi.org/10.1074/jbc.M115.698282 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | erythrocyte |
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| | Erythrocytes |
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| | Humans |
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| | infectious disease |
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| | invasion |
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| | malaria |
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| | Merozoite Surface Protein 1 |
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| | Merozoites |
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| | Multiprotein Complexes |
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| | Plasmodium falciparum |
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| | protein complex |
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| K10plus-PPN: | 1699321469 |
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| Verknüpfungen: | → Zeitschrift |
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Multiple plasmodium falciparum merozoite surface protein 1 complexes mediate merozoite binding to human erythrocytes / Lin, Clara S. [VerfasserIn]; April 1, 2016 (Online-Ressource)
