| |  Online-Ressource |
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| Verfasst von: | Archer, Tenley C. [VerfasserIn]  |
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| | Ehrenberger, Tobias [VerfasserIn] |
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| | Mundt, Filip [VerfasserIn] |
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| | Gold, Maxwell P. [VerfasserIn] |
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| | Krug, Karsten [VerfasserIn] |
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| | Mah, Clarence K. [VerfasserIn] |
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| | Mahoney, Elizabeth L. [VerfasserIn] |
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| | Daniel, Colin J. [VerfasserIn] |
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| | LeNail, Alexander [VerfasserIn] |
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| | Ramamoorthy, Divya [VerfasserIn] |
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| | Mertins, Philipp [VerfasserIn] |
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| | Mani, D. R. [VerfasserIn] |
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| | Zhang, Hailei [VerfasserIn] |
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| | Gillette, Michael A. [VerfasserIn] |
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| | Clauser, Karl [VerfasserIn] |
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| | Noble, Michael [VerfasserIn] |
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| | Tang, Lauren C. [VerfasserIn] |
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| | Pierre-François, Jessica [VerfasserIn] |
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| | Silterra, Jacob [VerfasserIn] |
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| | Jensen, James [VerfasserIn] |
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| | Tamayo, Pablo [VerfasserIn] |
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| | Korshunov, Andrey [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Northcott, Paul A. [VerfasserIn] |
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| | Sears, Rosalie C. [VerfasserIn] |
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| | Lipton, Jonathan O. [VerfasserIn] |
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| | Carr, Steven A. [VerfasserIn] |
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| | Mesirov, Jill P. [VerfasserIn] |
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| | Pomeroy, Scott L. [VerfasserIn] |
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| | Fraenkel, Ernest [VerfasserIn] |
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| Titel: | Proteomics, post-translational modifications, and integrative analyses reveal molecular heterogeneity within medulloblastoma subgroups |
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| Verf.angabe: | Tenley C. Archer, Tobias Ehrenberger, Filip Mundt, Maxwell P. Gold, Karsten Krug, Clarence K. Mah, Elizabeth L. Mahoney, Colin J. Daniel, Alexander LeNail, Divya Ramamoorthy, Philipp Mertins, D. R. Mani, Hailei Zhang, Michael A. Gillette, Karl Clauser, Michael Noble, Lauren C. Tang, Jessica Pierre-François, Jacob Silterra, James Jensen, Pablo Tamayo, Andrey Korshunov, Stefan M. Pfister, Marcel Kool, Paul A. Northcott, Rosalie C. Sears, Jonathan O. Lipton, Steven A. Carr, Jill P. Mesirov, Scott L. Pomeroy, and Ernest Fraenkel |
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| E-Jahr: | 2018 |
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| Jahr: | September 10, 2018 |
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| Umfang: | 23 S. |
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| Fussnoten: | Gesehen am 03.06.2020 |
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| Titel Quelle: | Enthalten in: Cancer cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2002 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 34(2018), 3, Seite 396-410, e1-e8 |
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| ISSN Quelle: | 1878-3686 |
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| Abstract: | There is a pressing need to identify therapeutic targets in tumors with low mutation rates such as the malignant pediatric brain tumor medulloblastoma. To address this challenge, we quantitatively profiled global proteomes and phospho-proteomes of 45 medulloblastoma samples. Integrated analyses revealed that tumors with similar RNA expression vary extensively at the post-transcriptional and post-translational levels. We identified distinct pathways associated with two subsets of SHH tumors, and found post-translational modifications of MYC that are associated with poor outcomes in group 3 tumors. We found kinases associated with subtypes and showed that inhibiting PRKDC sensitizes MYC-driven cells to radiation. Our study shows that proteomics enables a more comprehensive, functional readout, providing a foundation for future therapeutic strategies. |
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| DOI: | doi:10.1016/j.ccell.2018.08.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ccell.2018.08.004 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1535610818303581 |
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| | DOI: https://doi.org/10.1016/j.ccell.2018.08.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | mass spectrometry |
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| | medulloblastoma |
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| | multi-omics |
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| | MYC |
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| | network integration |
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| | NU-7441 |
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| | phospho-proteomics |
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| | proteo-genomics |
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| | radio sensitization |
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| | SHH |
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| K10plus-PPN: | 1699322309 |
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| Verknüpfungen: | → Zeitschrift |
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Proteomics, post-translational modifications, and integrative analyses reveal molecular heterogeneity within medulloblastoma subgroups / Archer, Tenley C. [VerfasserIn]; September 10, 2018 (Online-Ressource)
