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Verfasst von:Dietrich, Jens Erik [VerfasserIn]   i
 Freis, Alexander [VerfasserIn]   i
 Beedgen, Franziska [VerfasserIn]   i
 Horn, Kyra von [VerfasserIn]   i
 Holschbach, Verena [VerfasserIn]   i
 Liebscher, Julia [VerfasserIn]   i
 Strowitzki, Thomas [VerfasserIn]   i
 Germeyer, Ariane [VerfasserIn]   i
Titel:Intraindividual embryo morphokinetics are not affected by a switch of the ovarian stimulation protocol between GnRH agonist vs. antagonist regimens in consecutive cycles
Verf.angabe:Jens E. Dietrich, Alexander Freis, Franziska Beedgen, Kyra von Horn, Verena Holschbach, Julia Liebscher, Thomas Strowitzki, Ariane Germeyer
E-Jahr:2020
Jahr:28 April 2020
Umfang:9 S.
Fussnoten:Gesehen am 04.06.2020
Titel Quelle:Enthalten in: Frontiers in endocrinology
Ort Quelle:Lausanne : Frontiers Research Foundation, 2010
Jahr Quelle:2020
Band/Heft Quelle:11(2020), Artikel-ID 246
ISSN Quelle:1664-2392
Abstract:Background The impact of controlled ovarian stimulation (COS) during medically assisted reproduction (MAR) on human embryogenesis is still unclear. Therefore, we investigated if early embryonic development is affected by the type of gonadotropin-releasing hormone (GnRH) analogue used to prevent a premature LH surge. We compared embryo morphology and morphokinetics between GnRH agonist and antagonist cycles, both involving human chorionic gonadotropin (hCG)-trigger. To reduce possible confounding factors, we used intraindividual comparison of embryo morphokinetics in consecutive treatment cycles of the same patients that underwent a switch in the COS protocol. Methods This retrospective cohort study analyzed morphokinetics of embryos from patients (n= 49) undergoing a switch in COS protocols between GnRH agonists followed by GnRH antagonists, or vice versa, after culture in a time-lapse incubator (EmbryoScope®, Vitrolife) in our clinic between 06/2011 and 11/2016 (n= 49 GnRH agonist cycles with n= 172 embryos; n= 49 GnRH antagonist cycles with n= 163 embryos). Among time-lapse cycles we included all embryos of the two consecutive cycles before and after a switch in the type of COS in the same patient. In-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) was performed and embryos were imaged up to day 5. Data were analyzed using Mann-Whitney U test or Fisher’s exact test. The significance level was set to p= 0.05. Patients with preimplantation genetic screening cycles were excluded. Results The mean age (years ± standard deviation) of patients at the time of treatment was 35.7 ± 4.3 (GnRH agonist) and 35.8 ± 4.0 (GnRH antagonist) (p= 0.94). There was no statistically significant difference in the number of oocytes collected or the fertilization rate. The numbers of top quality embryos (TQE), good-quality embryos (GQE) or poor-quality embryos (PQE) were also not different in GnRH agonist versus antagonist cycles. We found no statistically significant difference between the analyzed morphokinetic parameters between the study groups. Conclusions Our finding supports the flexible use of GnRH analogues to optimize patient treatment for COS without affecting embryo morphokinetics.
DOI:doi:10.3389/fendo.2020.00246
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3389/fendo.2020.00246
 Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2020.00246/full
 DOI: https://doi.org/10.3389/fendo.2020.00246
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:GnRH agonist
 GnRH antagonist
 Human embryology
 Morphokinetics
 Time-Lapse Imaging
K10plus-PPN:1699797064
Verknüpfungen:→ Zeitschrift

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