| |  Online-Ressource |
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| Verfasst von: | Kurz, Christopher [VerfasserIn]  |
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| | Bauer, Julia [VerfasserIn] |
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| | Unholtz, Daniel [VerfasserIn] |
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| | Richter, Daniel [VerfasserIn] |
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| | Herfarth, Klaus [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Parodi, Katia [VerfasserIn] |
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| Titel: | Initial clinical evaluation of PET-based ion beam therapy monitoring under consideration of organ motion |
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| Verf.angabe: | Christopher Kurz, Julia Bauer, Daniel Unholtz, Daniel Richter, Klaus Herfarth, Jürgen Debus, Katia Parodi |
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| E-Jahr: | 2016 |
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| Jahr: | 28 January 2016 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 04.06.2020 |
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| Titel Quelle: | Enthalten in: Medical physics |
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| Ort Quelle: | Hoboken, NJ : Wiley, 1974 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 43(2016), 2, Seite 975-982 |
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| ISSN Quelle: | 2473-4209 |
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| | 1522-8541 |
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| Abstract: | Purpose: Intrafractional organ motion imposes considerable challenges to scanned ion beam therapy and demands for a thorough verification of the applied treatment. At the Heidelberg Ion-Beam Therapy Center (HIT), the scanned ion beam delivery is verified by means of postirradiation positron-emission-tomography (PET) imaging. This work presents a first clinical evaluation of PET-based treatment monitoring in ion beam therapy under consideration of target motion. Methods: Three patients with mobile liver lesions underwent scanned carbon ion irradiation at HIT and postirradiation PET/CT (x-ray-computed-tomography) imaging with a commercial scanner. Respiratory motion was recorded during irradiation and subsequent image acquisition. This enabled a time-resolved (4D) calculation of the expected irradiation-induced activity pattern and, for one patient where an additional 4D CT was acquired at the PET/CT scanner after treatment, a motion-compensated PET image reconstruction. For the other patients, PET data were reconstructed statically. To verify the treatment, calculated prediction and reconstructed measurement were compared with a focus on the ion beam range. Results: Results in the current three patients suggest that for motion amplitudes in the order of 2 mm there is no benefit from incorporating respiratory motion information into PET-based treatment monitoring. For a target motion in the order of 10 mm, motion-related effects become more severe and a time-resolved modeling of the expected activity distribution can lead to an improved data interpretation if a sufficient number of true coincidences is detected. Benefits from motion-compensated PET image reconstruction could not be shown conclusively at the current stage. Conclusions: The feasibility of clinical PET-based treatment verification under consideration of organ motion has been shown for the first time. Improvements in noise-robust 4D PET image reconstruction are deemed necessary to enhance the clinical potential. |
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| DOI: | doi:10.1118/1.4940356 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1118/1.4940356 |
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| | Volltext: https://aapm.onlinelibrary.wiley.com/doi/abs/10.1118/1.4940356 |
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| | DOI: https://doi.org/10.1118/1.4940356 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Analysis of motion |
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| | Biological material |
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| | Biomedical modeling |
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| | Cancer |
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| | Computed tomography |
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| | Computerised tomographs |
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| | computerised tomography |
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| | diagnostic radiography |
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| | Digital computing or data processing equipment or methods |
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| | Digital radiography |
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| | e.g. blood |
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| | Haemocytometers |
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| | Image data processing or generation |
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| | image reconstruction |
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| | in general |
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| | ion beam therapy |
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| | Ion beams |
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| | liver |
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| | Liver |
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| | lung |
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| | Measuring half-life of a radioactive substance |
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| | medical image processing |
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| | Medical image reconstruction |
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| | Medical X-ray imaging |
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| | motion compensation |
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| | object detection |
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| | organ motion |
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| | PET |
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| | Pneumodyamics |
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| | pneumodynamics |
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| | positron emission tomography |
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| | Positron emission tomography |
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| | Positron emission tomography (PET) |
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| | radiation therapy |
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| | Radiation therapy |
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| | Reconstruction |
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| | respiration |
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| | Scintigraphy |
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| | specially adapted for specific applications |
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| | treatment monitoring |
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| | Treatment strategy |
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| | urine |
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| K10plus-PPN: | 1699813019 |
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| Verknüpfungen: | → Zeitschrift |
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Initial clinical evaluation of PET-based ion beam therapy monitoring under consideration of organ motion / Kurz, Christopher [VerfasserIn]; 28 January 2016 (Online-Ressource)
