| Online-Ressource |
Verfasst von: | Vrhovac, Radovan [VerfasserIn]  |
| Labopin, M. [VerfasserIn]  |
| Ciceri, F. [VerfasserIn]  |
| Finke, J. [VerfasserIn]  |
| Holler, E. [VerfasserIn]  |
| Tischer, J. [VerfasserIn]  |
| Lioure, B. [VerfasserIn]  |
| Gribben, J. [VerfasserIn]  |
| Kanz, L. [VerfasserIn]  |
| Blaise, D. [VerfasserIn]  |
| Dreger, Peter [VerfasserIn]  |
| Held, G. [VerfasserIn]  |
| Arnold, R. [VerfasserIn]  |
| Nagler, A. [VerfasserIn]  |
| Mohty, M. [VerfasserIn]  |
Titel: | Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation |
Titelzusatz: | analysis of risk factors and treatment outcomes |
Verf.angabe: | R. Vrhovac, M. Labopin, F. Ciceri, J. Finke, E. Holler, J. Tischer, B. Lioure, J. Gribben, L. Kanz, D. Blaise, P. Dreger, G. Held, R. Arnold, A. Nagler and M. Mohty on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT) |
E-Jahr: | 2016 |
Jahr: | [2016] |
Jahr des Originals: | 2015 |
Umfang: | 8 S. |
Illustrationen: | Diagramme |
Fussnoten: | Published online 5 October 2015 ; Gesehen am 04.06.2020 |
Titel Quelle: | Enthalten in: Bone marrow transplantation |
Ort Quelle: | London : Springer Nature, 1997 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 51(2016), 2, Seite 186-193 |
ISSN Quelle: | 1476-5365 |
Abstract: | Limited therapeutic options are available after relapse of acute leukaemia following first reduced intensity conditioning haematopoietic stem cell transplantation (RIC1). A retrospective study on European Society for Blood and Marrow Transplantation (EBMT) registry data was performed on 234 adult patients with acute leukaemia who received a second RIC transplantation (RIC2) from 2000 to 2012 as a salvage treatment for relapse following RIC1. At the time of RIC2, 167 patients (71.4%) had relapsed or refractory disease, 49 (20.9%) were in second CR and 18 (7.7%) in third or higher CR. With a median follow-up of 21 (1.5-79) months after RIC2, 51 patients are still alive. At 2 years, the cumulative incidence of non-relapse mortality (NRM), relapse incidence (RI), leukaemia-free survival (LFS) and overall survival (OS) were 22.4% (95% confidence interval (CI): 17-28.4), 63.9% (56.7-70.1), 14.6% (8.8-18.5) and 20.5% (14.9-26.1), respectively. In patients with acute myelogenous, biphenotypic and undifferentiated leukaemia (representing 89.8% of all patients), duration of remission following RIC1 >225 days, presence of CR at RIC2, patient’s Karnofsky performance status >80 at RIC2 and non-myeloablative conditioning were found to be the strongest predictors of patients’ favourable outcome. |
DOI: | doi:10.1038/bmt.2015.221 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/bmt.2015.221 |
| Volltext: https://www.nature.com/articles/bmt2015221 |
| DOI: https://doi.org/10.1038/bmt.2015.221 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1699813094 |
Verknüpfungen: | → Zeitschrift |
Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation / Vrhovac, Radovan [VerfasserIn]; [2016] (Online-Ressource)