| |  Online-Ressource |
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| Verfasst von: | Mackenzie, Robertson [VerfasserIn]  |
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| | Kommoss, Stefan [VerfasserIn] |
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| | Winterhoff, Boris Jan Nils [VerfasserIn] |
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| | Kipp, Benjamin R. [VerfasserIn] |
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| | Garcia, Joaquin J. [VerfasserIn] |
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| | Voss, Jesse [VerfasserIn] |
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| | Halling, Kevin [VerfasserIn] |
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| | Karnezis, Anthony [VerfasserIn] |
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| | Senz, Janine [VerfasserIn] |
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| | Yang, Winnie [VerfasserIn] |
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| | Prigge, Elena-Sophie [VerfasserIn] |
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| | Reuschenbach, Miriam [VerfasserIn] |
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| | Knebel Doeberitz, Magnus von [VerfasserIn] |
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| | Gilks, Blake C. [VerfasserIn] |
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| | Huntsman, David G. [VerfasserIn] |
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| | Bakkum-Gamez, Jamie [VerfasserIn] |
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| | McAlpine, Jessica N. [VerfasserIn] |
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| | Anglesio, Michael S. [VerfasserIn] |
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| Titel: | Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms |
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| Verf.angabe: | Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez, Jessica N. McAlpine and Michael S. Anglesio |
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| E-Jahr: | 2015 |
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| Jahr: | 19 May 2015 |
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| Fussnoten: | Gesehen am 04.06.2020 |
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| Titel Quelle: | Enthalten in: BMC cancer |
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| Ort Quelle: | London : BioMed Central, 2001 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 15(2015) Artikel-Nummer 415, 10 Seiten |
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| ISSN Quelle: | 1471-2407 |
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| Abstract: | Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We undertook hotspot sequencing of 50 genes commonly mutated in human cancer across 69 mucinous ovarian tumors. Our goals were to establish the overall frequency of cancer-hotspot mutations across a large cohort, especially those tumors previously thought to be “RAS-pathway alteration negative”, using highly-sensitive next-generation sequencing as well as further explore a small number of cases with apparent heterogeneity in RAS-pathway activating alterations. |
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| DOI: | doi:10.1186/s12885-015-1421-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1186/s12885-015-1421-8 |
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| | DOI: https://doi.org/10.1186/s12885-015-1421-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1699813310 |
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| Verknüpfungen: | → Zeitschrift |
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Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms / Mackenzie, Robertson [VerfasserIn]; 19 May 2015 (Online-Ressource)
