Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants

• Verfasst von: Wallkamm, Veronika [VerfasserIn]
• Verfasst von: Rahm, Karolin [VerfasserIn]
• Verfasst von: Schmoll, Jana [VerfasserIn]
• Verfasst von: Kaufmann, Lilian [VerfasserIn]
• Verfasst von: Brinkmann, Eva-Maria [VerfasserIn]
• Verfasst von: Schunk, Jessica [VerfasserIn]
• Verfasst von: Kraft, Bianca [VerfasserIn]
• Verfasst von: Wedlich, Doris [VerfasserIn]
• Verfasst von: Gradl, Dietmar [VerfasserIn]
• Titel: Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants
• Verf.angabe: Veronika Wallkamm, Karolin Rahm, Jana Schmoll, Lilian T. Kaufmann, Eva Brinkmann, Jessica Schunk, Bianca Kraft, Doris Wedlich and Dietmar Gradl
• E-Jahr: 2016
• Jahr: 05 July 2016
• Umfang: 16 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 05.06.2020
• Titel Quelle: Enthalten in: BMC biology
• Ort Quelle: Berlin : Springer, 2003
• Jahr Quelle: 2016
• Band/Heft Quelle: 14(2016) Artikel-Nummer 55, 16 Seiten
• ISSN Quelle: 1741-7007
• DOI: doi:10.1186/s12915-016-0278-x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1699969116

Abstract

A tight regulation of the Wnt-signaling network, activated by 19 Wnt molecules and numerous receptors and co-receptors, is required for the establishment of a complex organism. Different branches of this Wnt-signaling network, including the canonical Wnt/β-catenin and the non-canonical Wnt/PCP, Wnt/Ror2 and Wnt/Ca2+ pathways, are assigned to distinct developmental processes and are triggered by certain ligand/receptor complexes. The Wnt-signaling molecules are closely related and it is still on debate whether the information for activating a specific branch is encoded by specific sequence motifs within a particular Wnt protein. The model organism Xenopus offers tools to distinguish between Wnt-signaling molecules activating distinct branches of the network.