Optical stimulation for restoration of motor function after spinal cord injury

• Verfasst von: Mallory, Grant W. [VerfasserIn]
• Verfasst von: Grahn, Peter J. [VerfasserIn]
• Verfasst von: Hachmann, Jan [VerfasserIn]
• Verfasst von: Lujan, J. Luis [VerfasserIn]
• Verfasst von: Lee, Kendall H. [VerfasserIn]
• Titel: Optical stimulation for restoration of motor function after spinal cord injury
• Verf.angabe: Grant W. Mallory, MD; Peter J. Grahn, BA; Jan T. Hachmann, BS; J. Luis Lujan, PhD;and Kendall H. Lee, MD, PhD
• E-Jahr: 2015
• Jahr: 2 February 2015
• Umfang: 8 S.
• Fussnoten: Gesehen am 05.06.2020
• Titel Quelle: Enthalten in: Mayo ClinicMayo Clinic proceedings
• Ort Quelle: Rochester, Minn. : Foundation, 1995
• Jahr Quelle: 2015
• Band/Heft Quelle: 90(2015), 2, Seite 300-307
• ISSN Quelle: 1942-5546
• DOI: doi:10.1016/j.mayocp.2014.12.004
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 169997277X

Abstract

Spinal cord injury can be defined as a loss of communication between the brain and the body due to disrupted pathways within the spinal cord. Although many promising molecular strategies have emerged to reduce secondary injury and promote axonal regrowth, there is still no effective cure, and recovery of function remains limited. Functional electrical stimulation (FES) represents a strategy developed to restore motor function without the need for regenerating severed spinal pathways. Despite its technological success, however, FES has not been widely integrated into the lives of spinal cord injury survivors. In this review, we briefly discuss the limitations of existing FES technologies. Additionally, we discuss how optogenetics, a rapidly evolving technique used primarily to investigate select neuronal populations within the brain, may eventually be used to replace FES as a form of therapy for functional restoration after spinal cord injury.