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| Verfasst von: | Marcos-Nickol, Veronica [VerfasserIn]  |
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| | Zhou-Suckow, Zhe [VerfasserIn] |
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| | Önder Yildirim, Ali [VerfasserIn] |
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| | Bohla, Alexander [VerfasserIn] |
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| | Hector, Andreas [VerfasserIn] |
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| | Vitkov, Ljubomir [VerfasserIn] |
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| | Krautgartner, Wolf Dietrich [VerfasserIn] |
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| | Stoiber, Walter [VerfasserIn] |
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| | Griese, Matthias [VerfasserIn] |
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| | Eickelberg, Oliver [VerfasserIn] |
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| | Mall, Marcus A. [VerfasserIn] |
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| | Hartl, Dominik [VerfasserIn] |
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| Titel: | Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction |
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| Verf.angabe: | Veronica Marcos, Zhe Zhou-Suckow, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Wolf Dietrich Krautgartner, Walter Stoiber, Matthias Griese, Oliver Eickelberg, Marcus A. Mall, and Dominik Hartl |
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| E-Jahr: | 2015 |
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| Jahr: | March 31, 2015 |
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| Fussnoten: | Gesehen am 08.06.2020 |
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| Titel Quelle: | Enthalten in: Mediators of inflammation |
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| Ort Quelle: | Sylvania, Ohio : Hindawi Publishing Corp., 1992 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | (2015) Artikel-Nummer 408935, 11 Seiten |
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| ISSN Quelle: | 1466-1861 |
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| Abstract: | Chronic obstructive lung disease determines morbidity and mortality of patients with cystic fibrosis (CF). CF airways are characterized by a nonresolving neutrophilic inflammation. After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs). NETs have been described to act in a beneficial way for innate host defense by bactericidal, fungicidal, and virucidal actions. On the other hand, excessive NET formation has been linked to the pathogenesis of autoinflammatory and autoimmune disease conditions. We quantified free DNA structures characteristic of NETs in airway fluids of CF patients and a mouse model with CF-like lung disease. Free DNA levels correlated with airflow obstruction, fungal colonization, and CXC chemokine levels in CF patients and CF-like mice. When viewed in combination, our results demonstrate that neutrophilic inflammation in CF airways is associated with abundant free DNA characteristic for NETosis, and suggest that free DNA may be implicated in lung function decline in patients with CF. |
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| DOI: | doi:10.1155/2015/408935 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1155/2015/408935 |
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| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397025/ |
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| | DOI: https://doi.org/10.1155/2015/408935 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1700130447 |
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| Verknüpfungen: | → Zeitschrift |
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Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction / Marcos-Nickol, Veronica [VerfasserIn]; March 31, 2015 (Online-Ressource)
