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Verfasst von:Mauceri, Daniela [VerfasserIn]   i
 Hertle, Anna M. [VerfasserIn]   i
 Schramm, Kathrin [VerfasserIn]   i
 Weiss, Ursula [VerfasserIn]   i
 Bading, Hilmar [VerfasserIn]   i
Titel:Nuclear calcium buffering capacity shapes neuronal architecture
Verf.angabe:Daniela Mauceri, Anna M. Hagenston, Kathrin Schramm, Ursula Weiss, and Hilmar Bading
E-Jahr:2015
Jahr:July 31, 2015
Umfang:11 S.
Fussnoten:Gesehen am 09.06.2020
Titel Quelle:Enthalten in: JBC papers in press
Ort Quelle:Bethesda, MD. : American Soc. for Biochemistry and Molecular Biology, 2003
Jahr Quelle:2015
Band/Heft Quelle:290(2015), 38, Seite 23039-23049
ISSN Quelle:1083-351X
Abstract:Calcium-binding proteins (CaBPs) such as parvalbumin are part of the cellular calcium buffering system that determines intracellular calcium diffusion and influences the spatiotemporal dynamics of calcium signals. In neurons, CaBPs are primarily localized to the cytosol and function, for example, in nerve terminals in short-term synaptic plasticity. However, CaBPs are also expressed in the cell nucleus, suggesting that they modulate nuclear calcium signals, which are key regulators of neuronal gene expression. Here we show that the calcium buffering capacity of the cell nucleus in mouse hippocampal neurons regulates neuronal architecture by modulating the expression levels of VEGFD and the complement factor C1q-c, two nuclear calcium-regulated genes that control dendrite geometry and spine density, respectively. Increasing the levels of nuclear calcium buffers by means of expression of a nuclearly targeted form of parvalbumin fused to mCherry (PV.NLS-mC) led to a reduction in VEGFD expression and, as a result, to a decrease in total dendritic length and complexity. In contrast, mRNA levels of the synapse pruning factor C1q-c were increased in neurons expressing PV.NLS-mC, causing a reduction in the density and size of dendritic spines. Our results establish a close link between nuclear calcium buffering capacity and the transcription of genes that determine neuronal structure. They suggest that the development of cognitive deficits observed in neurological conditions associated with CaBP deregulation may reflect the loss of necessary structural features of dendrites and spines.
DOI:doi:10.1074/jbc.M115.654962
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1074/jbc.M115.654962
 Volltext: http://www.jbc.org/content/290/38/23039
 DOI: https://doi.org/10.1074/jbc.M115.654962
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:calcium
 calcium binding protein
 dendrite
 gene expression
 signal transduction
 synapse
K10plus-PPN:1700216805
Verknüpfungen:→ Zeitschrift

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