| |  Online-Ressource |
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| Verfasst von: | Weidler, Sophia [VerfasserIn]  |
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| | Sommerburg, Olaf [VerfasserIn] |
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| | Mall, Marcus A. [VerfasserIn] |
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| | Hoffmann, Georg Friedrich [VerfasserIn] |
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| | Kohlmüller, Dirk [VerfasserIn] |
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| | Okun, Jürgen G. [VerfasserIn] |
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| Titel: | A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening |
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| Verf.angabe: | Sophia Weidler, Konrad H. Stopsack, Jutta Hammermann, Olaf Sommerburg, Marcus A. Mall, Georg F. Hoffmann, Dirk Kohlmüller, Jürgen G. Okun, Milan Macek, Felix Votava, Veronika Krulišová, Miroslava Balaščaková, Veronika Skalická, Min Ae Lee-Kirsch, Marina Stopsack |
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| E-Jahr: | 2016 |
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| Jahr: | 22 July 2016 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 09.06.2020 |
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| Titel Quelle: | Enthalten in: Journal of cystic fibrosis |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 2002 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 15(2016), 6, Seite 752-758 |
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| ISSN Quelle: | 1873-5010 |
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| Abstract: | In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) can be used as screening parameters. We evaluated the IRT×PAP product as second-tier parameter in CFNBS in newborns with elevated IRT. - Methods - Data on 410,111 screened newborns including 78 patients with classical cystic fibrosis (CF) from two European centers were retrospectively analyzed by discrimination analysis to identify a screening protocol with optimal cutoffs. We also studied differences in PAP measurement methods and the association of IRT and PAP with age. PAP values differed systematically between fluorometric and photometric assays. The IRT×PAP product showed better discrimination for classical CF than PAP only as second-tier screening parameter (p<0.001). In CF patients, IRT decreased while PAP values remained high over years. In newborns without CF, IRT decreased after birth over weeks while PAP increased within days. The IRT×PAP product performs well as second-tier cutoff parameter for CFNBS. Screening quality parameters depend on the analytic method and on age at blood collection. |
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| DOI: | doi:10.1016/j.jcf.2016.07.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jcf.2016.07.002 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1569199316305598 |
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| | DOI: https://doi.org/10.1016/j.jcf.2016.07.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cutoff |
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| | Cystic fibrosis |
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| | Immunoreactive trypsinogen |
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| | Newborn screening |
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| | Pancreatitis-associated protein |
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| K10plus-PPN: | 1700234242 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening / Weidler, Sophia [VerfasserIn]; 22 July 2016 (Online-Ressource)
