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Verfasst von:Jin, Yinhua [VerfasserIn]   i
 Ha, Nati [VerfasserIn]   i
 Xiang, Jinyi [VerfasserIn]   i
 Maldera, Julieta [VerfasserIn]   i
 Edgar, Bruce [VerfasserIn]   i
Titel:EGFR/Ras signaling controls drosophila intestinal stem cell proliferation via capicua-regulated genes
Verf.angabe:Yinhua Jin, Nati Ha, Marta Forés, Jinyi Xiang, Christine Gläßer, Julieta Maldera, Gerardo Jiménez, Bruce A. Edgar
E-Jahr:2015
Jahr:December 18, 2015
Umfang:27 S.
Fussnoten:Gesehen am 09.06.2020
Titel Quelle:Enthalten in: Public Library of SciencePLoS Genetics
Ort Quelle:San Francisco, Calif. : Public Library of Science, 2005
Jahr Quelle:2015
Band/Heft Quelle:11(2015,12) Artikel-Nummer e1005634, 27 Seiten
ISSN Quelle:1553-7404
Abstract:Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs). Following damage or stress the intestinal epithelium produces ligands that activate the epidermal growth factor receptor (EGFR) in ISCs. This promotes their growth and division and, thereby, epithelial regeneration. Here we demonstrate that the HMG-box transcriptional repressor, Capicua (Cic), mediates these functions of EGFR signaling. Depleting Cic in ISCs activated them for division, whereas overexpressed Cic inhibited ISC proliferation and midgut regeneration. Epistasis tests showed that Cic acted as an essential downstream effector of EGFR/Ras signaling, and immunofluorescence showed that Cic’s nuclear localization was regulated by EGFR signaling. ISC-specific mRNA expression profiling and DNA binding mapping using DamID indicated that Cic represses cell proliferation via direct targets including string (Cdc25), Cyclin E, and the ETS domain transcription factors Ets21C and Pointed (pnt). pnt was required for ISC over-proliferation following Cic depletion, and ectopic pnt restored ISC proliferation even in the presence of overexpressed dominant-active Cic. These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila ISCs.
DOI:doi:10.1371/journal.pgen.1005634
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pgen.1005634
 Volltext: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005634
 DOI: https://doi.org/10.1371/journal.pgen.1005634
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cell cycle and cell division
 Cloning
 DNA transcription
 Drosophila melanogaster
 EGFR signaling
 Stem cells
 Transcription factors
 Transcriptional control
K10plus-PPN:1700238701
Verknüpfungen:→ Zeitschrift

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