Blood-sampling collection prior to surgery may have a significant influence upon biomarker concentrations measured

• Verfasst von: Kahn, Nicolas [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Verfasst von: Schneider, Marc [VerfasserIn]
• Verfasst von: Meister, Michael [VerfasserIn]
• Verfasst von: Muley, Thomas [VerfasserIn]
• Titel: Blood-sampling collection prior to surgery may have a significant influence upon biomarker concentrations measured
• Verf.angabe: Nicolas Kahn, Julia Riedlinger, Markus Roeßler, Christina Rabe, Michael Lindner, Ina Koch, Sabine Schott-Hildebrand, Felix J Herth, Marc A Schneider, Michael Meister and Thomas R Muley
• E-Jahr: 2015
• Jahr: 31 July 2015
• Umfang: 7 S.
• Fussnoten: Gesehen am 17.06.2020
• Titel Quelle: Enthalten in: Clinical proteomics
• Ort Quelle: Totowa, NJ : Humana Press, 2004
• Jahr Quelle: 2015
• Band/Heft Quelle: 12(2015,1) Artikel-Nummer 19, 7 Seiten
• ISSN Quelle: 1559-0275
• DOI: doi:10.1186/s12014-015-9093-6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1700336134

Abstract

Biomarkers can be subtle tools to aid the diagnosis, prognosis and monitoring of therapy and disease progression. The validation of biomarkers is a cumbersome process involving many steps. Serum samples from lung cancer patients were collected in the framework of a larger study for evaluation of biomarkers for early detection of lung cancer. The analysis of biomarker levels measured revealed a noticeable difference in certain biomarker values that exhibited a dependence of the time point and setting of the sampling. Biomarker concentrations differed significantly if taken before or after the induction of anesthesia and if sampled via venipuncture or arterial catheter.