Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)

• Verfasst von: Seitz, Helmut K. [VerfasserIn]
• Verfasst von: Mueller, Sebastian [VerfasserIn]
• Verfasst von: Hellerbrand, Claus [VerfasserIn]
• Verfasst von: Liangpunsakul, Suthat [VerfasserIn]
• Titel: Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD)
• Verf.angabe: Helmut K. Seitz, Sebastian Mueller, Claus Hellerbrand, Suthat Liangpunsakul
• E-Jahr: 2015
• Jahr: June 2015
• Umfang: 5 S.
• Fussnoten: Gesehen am 16.06.2020
• Titel Quelle: Enthalten in: Hepatobiliary surgery and nutrition
• Ort Quelle: Hong Kong : AME Publishing Co., 2012
• Jahr Quelle: 2015
• Band/Heft Quelle: 4(2015), 3, Seite 147-151
• ISSN Quelle: 2304-389X
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1700636863

Abstract

A number of epidemiologic studies show a protective effect of light to moderate daily alcohol consumption on the development of non-alcoholic fatty liver disease (NAFLD). Although these small amounts of ethanol may prevent fatty liver, they may also be a risk factor for other diseases such as breast and colon cancer. Those individuals who have underlying hepatic steatosis or non-alcoholic steatohepatitis (NASH) should not use ethanol chronically since the data available at present do not support a beneficial effect of alcohol in this situation. Especially overweight and obese individuals may be more susceptible towards alcohol even at moderate doses. Animal experiments show a negative effect of ethanol on liver histology in either dietary or genetic NASH models. In addition, patients with NASH reveal a significant increased risk for hepatocellular cancer (HCC) even with social alcohol consumption. Thus, subjects with underlying NASH should abstain from alcohol at any amounts.