Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam

• Verfasst von: Alberts, Catharina J. [VerfasserIn]
• Verfasst von: Jeske, Rima [VerfasserIn]
• Verfasst von: Martel, Catherine de [VerfasserIn]
• Verfasst von: Hollander, Wouter J. den [VerfasserIn]
• Verfasst von: Michel, Angelika [VerfasserIn]
• Verfasst von: Prins, Maria [VerfasserIn]
• Verfasst von: Snijder, Marieke B. [VerfasserIn]
• Verfasst von: Loeff, Maarten F. Schim van der [VerfasserIn]
• Verfasst von: Waterboer, Tim [VerfasserIn]
• Titel: Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam
• Titelzusatz: the HELIUS study
• Verf.angabe: Catharina J. Alberts, Rima Jeske, Catherine de Martel, Wouter J. den Hollander, Angelika Michel, Maria Prins, Marieke B. Snijder, Maarten F. Schim van der Loeff, Tim Waterboer
• E-Jahr: 2020
• Jahr: 09 March 2020
• Umfang: 14 S.
• Fussnoten: Gesehen am 16.06.2020
• Titel Quelle: Enthalten in: Helicobacter
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1996
• Jahr Quelle: 2020
• Band/Heft Quelle: 25(2020,3) Artikel-Nummer e12687, 14 Seiten
• ISSN Quelle: 1523-5378
• DOI: doi:10.1111/hel.12687
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cross-sectional study
• Sach-SW: ethnicity
• Sach-SW: general population
• Sach-SW: Helicobacter pylori
• Sach-SW: migrants
• Sach-SW: seroprevalence
• K10plus-PPN: 1700640747

Abstract

Background Helicobacter pylori prevalence varies greatly worldwide. We explored the prevalence of H. pylori and CagA seropositivity among adults aged 18-44 years living in the Netherlands by ethnicity and migration status (first vs second generation). Materials and Methods Participants from six different ethnic groups were selected from the population-based multi-ethnic HELIUS study in Amsterdam, the Netherlands. Serum samples were tested for H. pylori antigens using a validated Luminex-based multiplex serology assay. Prevalence ratios were estimated using Poisson regression analysis. Results A total of 4683 participants aged 18-44 years were randomly selected based on sex, ethnicity, and age. H. pylori seroprevalence was highest in the Ghanaian group (84%), followed by Moroccan (81%), Turkish (66%), African Surinamese (51%), South-Asian Surinamese (48%), and Dutch (17%) participants. All ethnic minority groups had a significantly higher risk of being H. pylori seropositive compared to the Dutch group. This association was strongest among participants born outside the Netherlands (first generation), but was still significant and apparent among second-generation participants. Among first-generation participants, all groups, except the Moroccans, had a significantly higher proportion of individuals with a cagA + H. pylori strain compared to the Dutch participants. Conclusion Helicobacter pylori seroprevalence among first-generation migrants is high in the Netherlands and remains elevated among second-generation migrants (ie, those born in the Netherlands). High exposure to H. pylori, and especially to the more virulent cagA+ strain, highlights the need for tailored prevention of gastric diseases (notably peptic ulcers and cancers) among migrants.