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Verfasst von:Bretana, Neil [VerfasserIn]   i
 Gray, Richard R. [VerfasserIn]   i
 Cunningham, Evan B. [VerfasserIn]   i
 Betz-Stablein, Brigid [VerfasserIn]   i
 Ribeiro, Ruy [VerfasserIn]   i
 Graw, Frederik [VerfasserIn]   i
 Luciani, Fabio [VerfasserIn]   i
 Lloyd, Andrew R. [VerfasserIn]   i
Titel:Combined treatment and prevention strategies for hepatitis C virus elimination in the prisons in New South Wales
Titelzusatz:a modelling study
Verf.angabe:Neil A. Bretana, Richard R. Gray, Evan B. Cunningham, Brigid Betz-Stablein, Ruy Ribeiro, Frederik Graw, Fabio Luciani, Andrew R. Lloyd
Jahr:2020
Jahr des Originals:2019
Umfang:13 S.
Fussnoten:First published: 21 October 2019 ; Gesehen am 16.06.2020
Titel Quelle:Enthalten in: Addiction
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1993
Jahr Quelle:2020
Band/Heft Quelle:115(2020), 5, Seite 901-913
ISSN Quelle:1360-0443
Abstract:Background and aims Australia is currently on track to meet the World Health Organization (WHO) global hepatitis C virus (HCV) elimination goals by 2030, reflecting universal subsidized access to testing and direct-acting antiviral (DAA) treatment. In New South Wales, DAA treatment in prisons has scaled-up substantially, with 1000 prisoners treated in 2017. However, HCV prevalence and incidence in this setting is high, which could undermine elimination efforts. This study aimed to test the preventative effects of DAA treatment scale-up, opiate substitution treatment (OST) and needle and syringe programme (NSP) strategies for prisons. Design Modelling study using an individual-based mathematical model of a typical prison setting. The model was calibrated against Australian epidemiological data sets and executed in-prison events for each individual daily, including movements between prisons, changes in risk behaviour and uptake of prevention measures such as OST and NSP, as well as DAA treatment. Scenarios were projected from 2018 to 2030. Setting New South Wales prisons. Participants New South Wales prisoners. Measurements Variables including prison populations, prevalence and incidence rate were calculated. Prisoners were described by demographic characteristics, HCV infection history, risk behaviours and accessing treatment and prevention measures in varied security settings. Findings Increasing the number of prisoners treated for HCV to 2000 annually was projected to reduce the HCV incidence rate to 8.69 [95% confidence interval (CI) = 8.17, 9.20] per 100 person-years (100 p.y.). Combined treatment and prevention strategies were necessary to reduce the projected incidence rate to 5.22 (95% CI = 5.13, 5.52) per 100 p.y. Considering the expected reductions in the prevalence of chronic HCV in the Australian community, incidence rate was predicted to drop to 0.93 (95% CI = 0.92, 0.98) per 100 p.y. by 2030. Conclusions This model, which simulates prison scenarios to inform Australia's national hepatitis C virus elimination efforts, suggests that continued direct-acting antiviral (coverage in the community combined with a moderate increase of direct-acting antiviral treatments in prisons, and introduction of improved harm reduction via opiate substitution treatment and/or needle and syringe programmes, makes hepatitis C virus elimination feasible in Australian prisons.
DOI:doi:10.1111/add.14830
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/add.14830
 DOI: https://doi.org/10.1111/add.14830
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:australia
 burden
 Direct-acting antiviral
 hcv
 hepatitis C virus
 hiv
 infection
 injecting drug-use
 modelling
 needle and syringe exchange programme
 opioid substitution treatment
 people
 prevention
 prisons
 risk behaviors
 transmission
 treatment
 tuberculosis
K10plus-PPN:1700646818
Verknüpfungen:→ Zeitschrift

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