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| Verfasst von: | Shimizu, Noriaki [VerfasserIn]  |
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| | Maruyama, Takako [VerfasserIn] |
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| | Yoshikawa, Noritada [VerfasserIn] |
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| | Matsumiya, Ryo [VerfasserIn] |
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| | Ma, Yanxia [VerfasserIn] |
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| | Ito, Naoki [VerfasserIn] |
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| | Tasaka, Yuki [VerfasserIn] |
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| | Kuribara-Souta, Akiko [VerfasserIn] |
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| | Miyata, Keishi [VerfasserIn] |
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| | Oike, Yuichi [VerfasserIn] |
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| | Berger, Stefan [VerfasserIn] |
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| | Schütz, Günther [VerfasserIn] |
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| | Takeda, Shin’ichi [VerfasserIn] |
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| | Tanaka, Hirotoshi [VerfasserIn] |
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| Titel: | A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling |
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| Verf.angabe: | Noriaki Shimizu, Takako Maruyama, Noritada Yoshikawa, Ryo Matsumiya, Yanxia Ma, Naoki Ito, Yuki Tasaka, Akiko Kuribara-Souta, Keishi Miyata, Yuichi Oike, Stefan Berger, Günther Schütz, Shin’ichi Takeda & Hirotoshi Tanaka |
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| E-Jahr: | 2015 |
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| Jahr: | 1 April 2015 |
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| Teil: | volume:6 |
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| | year:2015 |
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| Fussnoten: | Gesehen am 17.06.2020 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 6(2015) Artikel-Nummer 6693, 14 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is tightly controlled by the hypothalamus-pituitary-adrenal signalling axis via a glucocorticoid-driven transcriptional programme. Here we unravel the physiological significance of this catabolic process using skeletal muscle-specific glucocorticoid receptor (GR) knockout (GRmKO) mice. These mice have increased muscle mass but smaller adipose tissues. Metabolically, GRmKO mice show a drastic shift of energy utilization and storage in muscle, liver and adipose tissues. We demonstrate that the resulting depletion of plasma alanine serves as a cue to increase plasma levels of fibroblast growth factor 21 (FGF21) and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues. We propose that this skeletal muscle-liver-fat signalling axis may serve as a target for the development of therapies against various metabolic diseases, including obesity. |
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| DOI: | doi:10.1038/ncomms7693 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/ncomms7693 |
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| | Volltext: https://www.nature.com/articles/ncomms7693 |
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| | DOI: https://doi.org/10.1038/ncomms7693 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1700738380 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling / Shimizu, Noriaki [VerfasserIn]; 1 April 2015 (Online-Ressource)
