| Online-Ressource |
Verfasst von: | Shimizu, Noriaki [VerfasserIn]  |
| Maruyama, Takako [VerfasserIn]  |
| Yoshikawa, Noritada [VerfasserIn]  |
| Matsumiya, Ryo [VerfasserIn]  |
| Ma, Yanxia [VerfasserIn]  |
| Ito, Naoki [VerfasserIn]  |
| Tasaka, Yuki [VerfasserIn]  |
| Kuribara-Souta, Akiko [VerfasserIn]  |
| Miyata, Keishi [VerfasserIn]  |
| Oike, Yuichi [VerfasserIn]  |
| Berger, Stefan [VerfasserIn]  |
| Schütz, Günther [VerfasserIn]  |
| Takeda, Shin’ichi [VerfasserIn]  |
| Tanaka, Hirotoshi [VerfasserIn]  |
Titel: | A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling |
Verf.angabe: | Noriaki Shimizu, Takako Maruyama, Noritada Yoshikawa, Ryo Matsumiya, Yanxia Ma, Naoki Ito, Yuki Tasaka, Akiko Kuribara-Souta, Keishi Miyata, Yuichi Oike, Stefan Berger, Günther Schütz, Shin’ichi Takeda & Hirotoshi Tanaka |
E-Jahr: | 2015 |
Jahr: | 1 April 2015 |
Teil: | volume:6 |
| year:2015 |
Fussnoten: | Gesehen am 17.06.2020 |
Titel Quelle: | Enthalten in: Nature Communications |
Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 6(2015) Artikel-Nummer 6693, 14 Seiten |
ISSN Quelle: | 2041-1723 |
Abstract: | Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is tightly controlled by the hypothalamus-pituitary-adrenal signalling axis via a glucocorticoid-driven transcriptional programme. Here we unravel the physiological significance of this catabolic process using skeletal muscle-specific glucocorticoid receptor (GR) knockout (GRmKO) mice. These mice have increased muscle mass but smaller adipose tissues. Metabolically, GRmKO mice show a drastic shift of energy utilization and storage in muscle, liver and adipose tissues. We demonstrate that the resulting depletion of plasma alanine serves as a cue to increase plasma levels of fibroblast growth factor 21 (FGF21) and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues. We propose that this skeletal muscle-liver-fat signalling axis may serve as a target for the development of therapies against various metabolic diseases, including obesity. |
DOI: | doi:10.1038/ncomms7693 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/ncomms7693 |
| Volltext: https://www.nature.com/articles/ncomms7693 |
| DOI: https://doi.org/10.1038/ncomms7693 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1700738380 |
Verknüpfungen: | → Zeitschrift |
¬A¬ muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling / Shimizu, Noriaki [VerfasserIn]; 1 April 2015 (Online-Ressource)