Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography

• Verfasst von: Siegle, Alexander Florian [VerfasserIn]
• Verfasst von: Trapp, Oliver [VerfasserIn]
• Titel: Implementation of Hadamard encoding for rapid multisample analysis in liquid chromatography
• Verf.angabe: Alexander F. Siegle, Oliver Trapp
• E-Jahr: 2015
• Jahr: 10 September 2015
• Umfang: 6 S.
• Fussnoten: Gesehen am 17.06.2020
• Titel Quelle: Enthalten in: Journal of separation science
• Ort Quelle: Weinheim : Wiley-VCH, 2000
• Jahr Quelle: 2015
• Band/Heft Quelle: 38(2015), 22, Seite 3839-3844
• ISSN Quelle: 1615-9314
• DOI: doi:10.1002/jssc.201500849
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Hadamard transformation
• Sach-SW: High-throughput screening
• Sach-SW: Liquid chromatography
• Sach-SW: Multiplexing
• K10plus-PPN: 170074769X

Abstract

Multiplexing based on pseudo-binary modulation sequences is known to increase the signal-to-noise ratio. In this work, Hadamard transform multiplexing is used in high-performance liquid chromatography to increase the sample throughput. Using structured modulation sequences to encode and control sample injections in combination with a fitting algorithm to deconvolute the complex data allowed us to evaluate convoluted chromatograms of up to 128 samples containing three and five analytes, respectively, with good accuracy (<2% deviation). In comparison to conventional high-performance liquid chromatography the analysis time could be reduced by 30 and 55%, respectively.