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| Verfasst von: | Lehmann, Helge Immo [VerfasserIn]  |
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| | Graeff, Christian [VerfasserIn] |
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| | Simoniello, Palma [VerfasserIn] |
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| | Constantinescu, Anna [VerfasserIn] |
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| | Takami, Mitsuru [VerfasserIn] |
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| | Lugenbiel, Patrick [VerfasserIn] |
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| | Richter, Daniel [VerfasserIn] |
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| | Eichhorn, Anna [VerfasserIn] |
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| | Prall, Matthias [VerfasserIn] |
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| | Kaderka, Robert [VerfasserIn] |
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| | Fiedler, Fine [VerfasserIn] |
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| | Helmbrecht, Stephan [VerfasserIn] |
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| | Fournier, Claudia [VerfasserIn] |
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| | Erbeldinger, Nadine [VerfasserIn] |
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| | Rahm, Ann-Kathrin [VerfasserIn] |
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| | Rivinius, Rasmus [VerfasserIn] |
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| | Thomas, Dierk [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Johnson, Susan B. [VerfasserIn] |
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| | Parker, Kay D. [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Asirvatham, Samuel J. [VerfasserIn] |
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| | Bert, Christoph [VerfasserIn] |
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| | Durante, Marco [VerfasserIn] |
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| | Packer, Douglas L. [VerfasserIn] |
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| Titel: | Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams |
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| Verf.angabe: | H. Immo Lehmann, Christian Graeff, Palma Simoniello, Anna Constantinescu, Mitsuru Takami, Patrick Lugenbiel, Daniel Richter, Anna Eichhorn, Matthias Prall, Robert Kaderka, Fine Fiedler, Stephan Helmbrecht, Claudia Fournier, Nadine Erbeldinger, Ann-Kathrin Rahm, Rasmus Rivinius, Dierk Thomas, Hugo A. Katus, Susan B. Johnson, Kay D. Parker, Jürgen Debus, Samuel J. Asirvatham, Christoph Bert, Marco Durante & Douglas L. Packer |
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| E-Jahr: | 2016 |
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| Jahr: | 20 December 2016 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 18.06.2020 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 6(2016) Artikel-Nummer 38895, 13 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac tissue in pigs. Doses of 25, 40, and 55 Gy were applied in forced-breath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left ventricle of intact animals. Procedural success was tracked by (1.) in-beam positron-emission tomography (PET) imaging; (2.) intracardiac voltage mapping with visible lesion on ultrasound; (3.) lesion outcomes in pathohistolgy. High doses (40-55 Gy) caused slowing and interruption of cardiac impulse propagation. Target fibrosis was the main mediator of the ablation effect. In irradiated tissue, apoptosis was present after 3, but not 6 months. Our study shows feasibility to use high-energy ion beams for creation of cardiac lesions that chronically interrupt cardiac conduction. |
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| DOI: | doi:10.1038/srep38895 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/srep38895 |
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| | Volltext: https://www.nature.com/articles/srep38895 |
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| | DOI: https://doi.org/10.1038/srep38895 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1701027224 |
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| Verknüpfungen: | → Zeitschrift |
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Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams / Lehmann, Helge Immo [VerfasserIn]; 20 December 2016 (Online-Ressource)
