Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Giesen, Nicola [VerfasserIn]  |
| Krämer, Isabelle [VerfasserIn]  |
| Schwarzbich, Mark-Alexander [VerfasserIn]  |
| Ho, Anthony Dick [VerfasserIn]  |
| Witzens-Harig, Mathias [VerfasserIn]  |
Titel: | Analysis of clinical characteristics and outcome of patients with previously untreated diffuse large B-cell lymphoma and renal involvement in the rituximab era |
Verf.angabe: | Nicola Lehners, Isabelle Krämer, Mark-Alexander Schwarzbich, Anthony D. Ho & Mathias Witzens-Harig |
E-Jahr: | 2016 |
Jahr: | 21 Mar 2016 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 18.06.2020 |
Titel Quelle: | Enthalten in: Leukemia and lymphoma |
Ort Quelle: | London [u.a.] : Taylor & Francis Group, 1989 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 57(2016), 11, Seite 2619-2625 |
ISSN Quelle: | 1029-2403 |
Abstract: | Renal involvement in patients with lymphoma is rare but associated with poor prognosis. We analyzed characteristics and outcome of 22 patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) and renal involvement treated with a rituximab-containing regimen in curative intent. The majority of patients presented in advanced disease, 86% were Ann Arbor stage ≥ III and had an IPI score ≥ 3. Renal impairment was present in 32%. Outcome was poor with three-year progression-free survival (PFS) 44% and three-year overall survival (OS) 52% and significantly worse compared to DLBCL without renal involvement (p < 0.01). Patients with high-risk IPI had a significantly inferior prognosis compared to intermediate-risk IPI (three-year OS 0% vs. 75%, p = 0.01) as did those with renal impairment. A high rate of central nervous system (CNS) relapse (8/22) was observed. Intravenous high-dose methotrexate and intrathecal therapy showed a trend toward prolonged time to CNS relapse. Implementation of CNS prophylaxis might therefore be considered in these high-risk patients. |
DOI: | doi:10.3109/10428194.2016.1157869 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3109/10428194.2016.1157869 |
| DOI: https://doi.org/10.3109/10428194.2016.1157869 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | chemotherapeutic approaches |
| lymphoma and Hodgkin disease |
| prognostication |
K10plus-PPN: | 1701039729 |
Verknüpfungen: | → Zeitschrift |
Analysis of clinical characteristics and outcome of patients with previously untreated diffuse large B-cell lymphoma and renal involvement in the rituximab era / Giesen, Nicola [VerfasserIn]; 21 Mar 2016 (Online-Ressource)
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