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Status: Bibliographieeintrag

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Verfasst von:Giesen, Nicola [VerfasserIn]   i
 Tabatabai, Julia [VerfasserIn]   i
 Prifert, Christiane [VerfasserIn]   i
 Wedde, Marianne [VerfasserIn]   i
 Puthenparambil, Joe [VerfasserIn]   i
 Weissbrich, Benedikt [VerfasserIn]   i
 Biere, Barbara [VerfasserIn]   i
 Schweiger, Brunhilde [VerfasserIn]   i
 Egerer, Gerlinde [VerfasserIn]   i
 Schnitzler, Paul [VerfasserIn]   i
Titel:Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders
Verf.angabe:Nicola Lehners, Julia Tabatabai, Christiane Prifert, Marianne Wedde, Joe Puthenparambil, Benedikt Weissbrich, Barbara Biere, Brunhilde Schweiger, Gerlinde Egerer, Paul Schnitzler
E-Jahr:2016
Jahr:February 11, 2016
Umfang:17 S.
Fussnoten:Gesehen am 18.06.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2016
Band/Heft Quelle:11(2016,2) Artikel-Nummer e0148258, 17 Seiten
ISSN Quelle:1932-6203
Abstract:Respiratory viruses are a cause of upper respiratory tract infections (URTI), but can be associated with severe lower respiratory tract infections (LRTI) in immunocompromised patients. The objective of this study was to investigate the genetic variability of influenza virus, parainfluenza virus and respiratory syncytial virus (RSV) and the duration of viral shedding in hematological patients. Nasopharyngeal swabs from hematological patients were screened for influenza, parainfluenza and RSV on admission as well as on development of respiratory symptoms. Consecutive swabs were collected until viral clearance. Out of 672 tested patients, a total of 111 patients (17%) were infected with one of the investigated viral agents: 40 with influenza, 13 with parainfluenza and 64 with RSV; six patients had influenza/RSV or parainfluenza/RSV co-infections. The majority of infected patients (n = 75/111) underwent stem cell transplantation (42 autologous, 48 allogeneic, 15 autologous and allogeneic). LRTI was observed in 48 patients, of whom 15 patients developed severe LRTI, and 13 patients with respiratory tract infection died. Phylogenetic analysis revealed a variety of influenza A(H1N1)pdm09, A(H3N2), influenza B, parainfluenza 3 and RSV A, B viruses. RSV A was detected in 54 patients, RSV B in ten patients. The newly emerging RSV A genotype ON1 predominated in the study cohort and was found in 48 (75%) of 64 RSV-infected patients. Furthermore, two distinct clusters were detected for RSV A genotype ON1, identical RSV G gene sequences in these patients are consistent with nosocomial transmission. Long-term viral shedding for more than 30 days was significantly associated with prior allogeneic transplantation (p = 0.01) and was most pronounced in patients with RSV infection (n = 16) with a median duration of viral shedding for 80 days (range 35-334 days). Long-term shedding of respiratory viruses might be a catalyzer of nosocomial transmission and must be considered for efficient infection control in immunocompromised patients.
DOI:doi:10.1371/journal.pone.0148258
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0148258
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148258
 DOI: https://doi.org/10.1371/journal.pone.0148258
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Hematology
 Influenza
 Influenza viruses
 Multiple myeloma
 Phylogenetic analysis
 Respiratory infections
 Respiratory syncytial virus
 Viral release
K10plus-PPN:170106314X
Verknüpfungen:→ Zeitschrift

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