Unconventional secretion of fibroblast growth factor 2

• Verfasst von: Steringer, Julia P. [VerfasserIn]
• Verfasst von: Müller, Hans-Michael [VerfasserIn]
• Verfasst von: Nickel, Walter [VerfasserIn]
• Titel: Unconventional secretion of fibroblast growth factor 2
• Titelzusatz: a novel type of protein translocation across membranes?
• Verf.angabe: Julia P. Steringer, Hans-Michael Müller and Walter Nickel
• Jahr: 2015
• Jahr des Originals: 2014
• Umfang: 9 S.
• Fussnoten: Available online 19 July 2014 ; Gesehen am 22.06.2020
• Titel Quelle: Enthalten in: Journal of molecular biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1959
• Jahr Quelle: 2015
• Band/Heft Quelle: 427(2015), 6, Part A, Seite 1202-1210
• ISSN Quelle: 1089-8638
• DOI: doi:10.1016/j.jmb.2014.07.012
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: fibroblast growth factor 2
• Sach-SW: formation of lipidic membrane pores
• Sach-SW: interleukin 1β
• Sach-SW: phosphoinositide-induced protein oligomerization
• Sach-SW: unconventional protein secretion
• K10plus-PPN: 1701919613

Abstract

N-terminal signal peptides are a hallmark of the vast majority of soluble secretory proteins that are transported along the endoplasmic reticulum/Golgi-dependent pathway. They are recognized by signal recognition particle, a process that initiates membrane translocation into the lumen of the endoplasmic reticulum followed by vesicular transport to the cell surface and release into the extracellular space. Beyond this well-established mechanism of protein secretion from eukaryotic cells, a number of extracellular proteins with critical physiological functions in immune surveillance and tissue organization are known to be secreted in a manner independent of signal recognition particle. Such processes have collectively been termed “unconventional protein secretion” and, while known for more than two decades, their underlying mechanisms are only beginning to emerge. Different types of unconventional secretory mechanisms have been described with the best-characterized example being based on direct translocation of cytoplasmic proteins across plasma membranes. The aim of this review is to critically assess our current knowledge of this type of unconventional secretion focusing on fibroblast growth factor 2 (FGF2) as the most established example.