FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas

• Verfasst von: Röhrich, Manuel [VerfasserIn]
• Verfasst von: Floca, Ralf [VerfasserIn]
• Verfasst von: Loi, Lisa [VerfasserIn]
• Verfasst von: Adeberg, Sebastian [VerfasserIn]
• Verfasst von: Windisch, Paul [VerfasserIn]
• Verfasst von: Giesel, Frederik L. [VerfasserIn]
• Verfasst von: Kratochwil, Clemens [VerfasserIn]
• Verfasst von: Flechsig, Paul [VerfasserIn]
• Verfasst von: Rathke, Hendrik [VerfasserIn]
• Verfasst von: Lindner, Thomas [VerfasserIn]
• Verfasst von: Loktev, Anastasia [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Haberkorn, Uwe [VerfasserIn]
• Verfasst von: Paech, Daniel [VerfasserIn]
• Titel: FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas
• Verf.angabe: Manuel Röhrich, Ralf Floca, Lisa Loi, Sebastian Adeberg, Paul Windisch, Frederik L. Giesel, Clemens Kratochwil, Paul Flechsig, Hendrik Rathke, Thomas Lindner, Anastasia Loktev, Heinz Peter Schlemmer, Uwe Haberkorn, Daniel Paech
• E-Jahr: 2020
• Jahr: 20 April 2020
• Umfang: 7 S.
• Fussnoten: Gesehen am 23.06.2020
• Titel Quelle: Enthalten in: European journal of radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2020
• Band/Heft Quelle: 127(2020), Artikel-ID 109021, Seite 1-7
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2020.109021
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ADC
• Sach-SW: CBV
• Sach-SW: FAP
• Sach-SW: Fibroblast activation protein
• Sach-SW: Glioblastoma
• Sach-SW: PET
• K10plus-PPN: 1701972158

Abstract

OBJECTIVES: Targeting Fibroblast Activation Protein (FAP) is a new approach for glioblastoma imaging. In a recent pilot study glioblastomas showed elevated tracer uptake with high intratumoral heterogeneity in projection on the corresponding T2w/FLAIR and contrast enhanced MRI lesions. In this study, we correlated FAP-specific signaling with apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) signals in MRI to further characterize the significance of FAP uptake. METHODS: Clinical PET/CT scans of 13 glioblastoma patients were performed post i. v. administration of 68Ga-labelled-FAP-specific tracer molecules. PET- and corresponding MRI-scans were co-registrated. 3d volumetric segmentations were performed of T2w/FLAIR lesions and contrast enhancing lesions within co-registrated MRI slides. Signal intensity values of FAP-specific PET signaling, ADC and rCBV were analyzed for their pixel wise correlation in each patient. Pooled estimates of the correlation coefficients were calculated by using the Fisher z-transformation. RESULTS: FAP-specific PET signals showed a moderately positive correlation with rCBV values which is more pronounced within the T2w/FLAIR lesion (pooled correlation 0,229) than in the contrast enhancing tumor region (pooled correlation 0.09). FAP-specific PET signals showed no correlation with ADC values. CONCLUSIONS: The moderately positive correlation of FAP-specific signals with rCBV values in MRI indicates that FAP-signaling is not independent from perfusion, but also does not only reflect intratumoral perfusion differences. The missing correlation of FAP-specific signals with ADC indicates that FAP-specific imaging does not reflect cell density, but the spot-like expression of FAP in glioblastomas. The clinical value of FAP-specific imaging needs further investigation.